Investigation of deformation of tablets according to breaking hardness

K. Hodi, P. Revesz, M. Miseta, B. Selmeczi

Research output: Contribution to journalArticle

Abstract

The authors were the first to test the breaking process of tablets in home respect. In experiments on the breaking of tablets a tablet hardness tester developed by the Chemical and Pharmaceutical Works Ltd. Chinoin (Budapest) was used. With an appropriate program, this permitted not only a qualitative evaluation of the breaking curves, but also an assessment of the breaking work relating to the breaking strength and even the work needed for various deformation processes. The concept of the breaking factor was introduced: this allows a differentiation of tablets even if the breaking strengths are the same (1-2 tablets, with two samples analysis; p <0.05). It is concluded that such breaking strength examinations contribute to a better understanding of the behaviour of substances during compression. These results can be very useful both in preformulation examinations and in tests on the prepared products.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalActa Pharmaceutica Hungarica
Volume64
Issue number2
Publication statusPublished - 1994

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Hardness
Tablets
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Investigation of deformation of tablets according to breaking hardness. / Hodi, K.; Revesz, P.; Miseta, M.; Selmeczi, B.

In: Acta Pharmaceutica Hungarica, Vol. 64, No. 2, 1994, p. 41-44.

Research output: Contribution to journalArticle

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