CNTF, COMT, DDR1, DISC1, DRD2, DRD3 és DTNBP1 kandidáns gének vizsgálata szkizofréniában: Eredmények a Magyar SCHIZOBANK Konzorcium vizsgálatából

Translated title of the contribution: Investigation of CNTF, COMT, DDR1, DISC1, DRD2, DRD3, and DTNBP1 candidate genes in schizophrenia: Results from the Hungarian SCHIZOBANK consortium

Benkovits Judit, Magyarósi Szilvia, Pulay Attila, Makkos Zoltán, Égerházi Anikó, Balogh Nóra, Álmos Péter, Likó István, Németh György, Molnár Mária Judit, Nagy László, Réthelyi János, Magyar SCHIZOBANK Konzorcium

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Schizophrenia is a chronic, debilitating psychiatric disorder characterized by heterogeneous clinical symptoms. Although the pathogenesis of this disorder is poorly understood, several lines of evidence support the role of both common and rare genetic variants in the etiology of schizophrenia. Common variants, single nucleotide polymorphisms can be investigated by candidate gene association studies or genome-wide association studies, while rare variants, single nucleotide variants are assessable by means of candidate gene resequencing or wholeexome and genome sequencing using next generation sequencing. In this study we investigated polymorphisms of 7 candidate genes in a Hungarian schizophrenia cohort. Candidate genes were chosen on the basis of previous results and biological plausibility. 390 patients were recruited in 5 centers in the framework of the Hungarian SCHIZOBANK Consortium, the schizophrenia sample was contrasted to 1069 healthy control individuals. In this sample SNPs of DDR1 and DRD2 genes demonstrated significant association with schizophrenia. The role of DDR1 and DRD2 genes in the etiology of schizophrenia warrant further investigation, based on their genomic localization and biological functions.

Translated title of the contributionInvestigation of CNTF, COMT, DDR1, DISC1, DRD2, DRD3, and DTNBP1 candidate genes in schizophrenia: Results from the Hungarian SCHIZOBANK consortium
Original languageHungarian
Pages (from-to)181-187
Number of pages7
JournalNeuropsychopharmacologia Hungarica
Volume18
Issue number4
Publication statusPublished - Dec 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Clinical Neurology

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    Judit, B., Szilvia, M., Attila, P., Zoltán, M., Anikó, É., Nóra, B., Péter, Á., István, L., György, N., Judit, M. M., László, N., János, R., & Magyar SCHIZOBANK Konzorcium (2016). CNTF, COMT, DDR1, DISC1, DRD2, DRD3 és DTNBP1 kandidáns gének vizsgálata szkizofréniában: Eredmények a Magyar SCHIZOBANK Konzorcium vizsgálatából. Neuropsychopharmacologia Hungarica, 18(4), 181-187.