Investigation of circulating endothelial progenitor cells and angiogenic and inflammatory cytokines during recovery from an episode of major depression

P. Döme, Zsuzsa Halmai, J. Dobos, J. Lazáry, X. Gonda, I. Kenessey, Timea Sallai, Zoltan Makkos, G. Faludi

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Abstract

Background: Epidemiological studies strongly suggest a bidirectional positive relationship between mood and cardiovascular disorders (CVD). Reduced numbers of circulating endothelial progenitor cells (cEPCs) are associated with elevated risks of CVD. Previously we demonstrated that patients with a current episode of major depression (MDE) have a decreased number of cEPCs. The role of vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF) has been demonstrated in the etiopathogenesis of depression. In addition these cytokines are also involved in regulation of the vascular system. This suggests that VEGF and/or TNF may also mediate the elevated risk of CVD associated with mood disorders. Methods: In the current investigation, which has a self-controlled study design, we examined changes in VEGF and TNF levels and - for the first time - changes in cEPC number during recovery from MDE. Results: Twenty-four patients with MDE were enrolled. The severity of their depressive symptoms improved significantly during the one-month treatment period (~ 50% decrease in MADRS score; P ≤ 0.001). We did not find significant differences between baseline and end-point levels of VEGF, TNF and the number of cEPCs. Conclusion: Our negative result for alteration in the number of cEPCs in the course of recovery from MDE raises several questions. Before discarding the number of cEPCs as a possible marker of depression - and/or elevated CV risk associated with it - our results would require confirmation in larger samples. Our results for TNF and VEGF do not contradict the findings of prior studies, since these were controversial.

Original languageEnglish
Pages (from-to)1159-1163
Number of pages5
JournalJournal of Affective Disorders
Volume136
Issue number3
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Depression
Cytokines
Vascular Endothelial Growth Factor A
Tumor Necrosis Factor-alpha
Mood Disorders
Endothelial Progenitor Cells
Blood Vessels
Epidemiologic Studies
Cell Count
Therapeutics

Keywords

  • Cardiovascular disorders
  • Depression
  • Endothelial progenitor cells
  • Mood disorders
  • Tumor necrosis factor
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

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title = "Investigation of circulating endothelial progenitor cells and angiogenic and inflammatory cytokines during recovery from an episode of major depression",
abstract = "Background: Epidemiological studies strongly suggest a bidirectional positive relationship between mood and cardiovascular disorders (CVD). Reduced numbers of circulating endothelial progenitor cells (cEPCs) are associated with elevated risks of CVD. Previously we demonstrated that patients with a current episode of major depression (MDE) have a decreased number of cEPCs. The role of vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF) has been demonstrated in the etiopathogenesis of depression. In addition these cytokines are also involved in regulation of the vascular system. This suggests that VEGF and/or TNF may also mediate the elevated risk of CVD associated with mood disorders. Methods: In the current investigation, which has a self-controlled study design, we examined changes in VEGF and TNF levels and - for the first time - changes in cEPC number during recovery from MDE. Results: Twenty-four patients with MDE were enrolled. The severity of their depressive symptoms improved significantly during the one-month treatment period (~ 50{\%} decrease in MADRS score; P ≤ 0.001). We did not find significant differences between baseline and end-point levels of VEGF, TNF and the number of cEPCs. Conclusion: Our negative result for alteration in the number of cEPCs in the course of recovery from MDE raises several questions. Before discarding the number of cEPCs as a possible marker of depression - and/or elevated CV risk associated with it - our results would require confirmation in larger samples. Our results for TNF and VEGF do not contradict the findings of prior studies, since these were controversial.",
keywords = "Cardiovascular disorders, Depression, Endothelial progenitor cells, Mood disorders, Tumor necrosis factor, Vascular endothelial growth factor",
author = "P. D{\"o}me and Zsuzsa Halmai and J. Dobos and J. Laz{\'a}ry and X. Gonda and I. Kenessey and Timea Sallai and Zoltan Makkos and G. Faludi",
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T1 - Investigation of circulating endothelial progenitor cells and angiogenic and inflammatory cytokines during recovery from an episode of major depression

AU - Döme, P.

AU - Halmai, Zsuzsa

AU - Dobos, J.

AU - Lazáry, J.

AU - Gonda, X.

AU - Kenessey, I.

AU - Sallai, Timea

AU - Makkos, Zoltan

AU - Faludi, G.

PY - 2012/2

Y1 - 2012/2

N2 - Background: Epidemiological studies strongly suggest a bidirectional positive relationship between mood and cardiovascular disorders (CVD). Reduced numbers of circulating endothelial progenitor cells (cEPCs) are associated with elevated risks of CVD. Previously we demonstrated that patients with a current episode of major depression (MDE) have a decreased number of cEPCs. The role of vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF) has been demonstrated in the etiopathogenesis of depression. In addition these cytokines are also involved in regulation of the vascular system. This suggests that VEGF and/or TNF may also mediate the elevated risk of CVD associated with mood disorders. Methods: In the current investigation, which has a self-controlled study design, we examined changes in VEGF and TNF levels and - for the first time - changes in cEPC number during recovery from MDE. Results: Twenty-four patients with MDE were enrolled. The severity of their depressive symptoms improved significantly during the one-month treatment period (~ 50% decrease in MADRS score; P ≤ 0.001). We did not find significant differences between baseline and end-point levels of VEGF, TNF and the number of cEPCs. Conclusion: Our negative result for alteration in the number of cEPCs in the course of recovery from MDE raises several questions. Before discarding the number of cEPCs as a possible marker of depression - and/or elevated CV risk associated with it - our results would require confirmation in larger samples. Our results for TNF and VEGF do not contradict the findings of prior studies, since these were controversial.

AB - Background: Epidemiological studies strongly suggest a bidirectional positive relationship between mood and cardiovascular disorders (CVD). Reduced numbers of circulating endothelial progenitor cells (cEPCs) are associated with elevated risks of CVD. Previously we demonstrated that patients with a current episode of major depression (MDE) have a decreased number of cEPCs. The role of vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF) has been demonstrated in the etiopathogenesis of depression. In addition these cytokines are also involved in regulation of the vascular system. This suggests that VEGF and/or TNF may also mediate the elevated risk of CVD associated with mood disorders. Methods: In the current investigation, which has a self-controlled study design, we examined changes in VEGF and TNF levels and - for the first time - changes in cEPC number during recovery from MDE. Results: Twenty-four patients with MDE were enrolled. The severity of their depressive symptoms improved significantly during the one-month treatment period (~ 50% decrease in MADRS score; P ≤ 0.001). We did not find significant differences between baseline and end-point levels of VEGF, TNF and the number of cEPCs. Conclusion: Our negative result for alteration in the number of cEPCs in the course of recovery from MDE raises several questions. Before discarding the number of cEPCs as a possible marker of depression - and/or elevated CV risk associated with it - our results would require confirmation in larger samples. Our results for TNF and VEGF do not contradict the findings of prior studies, since these were controversial.

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