Investigation of c-myc oncogene amplification in colorectal cancer

L. Kozma, I. Kiss, S. Szakáll, I. Ember

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Tumour DNA samples of 20 patients with colorectal carcinoma were tested for c-myc amplification, using a quantitative dot-blot hybridization. Statistical analysis involving clinical and histological parameters like degree of differentiation, Dukes' stage, TNM staging system, age, sex and severity of disease, was applied to estimate the prognostic value of c-myc amplification. The amplification of the investigated oncogene - 1.61-fold on the average - was found to significantly correlate with the presence of distant metastasis (corr. coeff.: 0.506, P <0.05) and the severe course of the disease (corr. coeff.: 0.468, P <0.05). This result supports the hypothesis that tumour cells with c-myc amplification represent a more malignant and aggressive phenotype. It is also worth noting that both c-myc amplification and formation of distant metastasis are late events in the progression of colorectal cancer, which accounts for the more severe course of the disease.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalCancer Letters
Volume81
Issue number2
DOIs
Publication statusPublished - Jun 30 1994

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myc Genes
Colorectal Neoplasms
Neoplasm Metastasis
Neoplasm Staging
Oncogenes
Neoplasms
Phenotype
DNA

Keywords

  • Amplification
  • c-myc oncogene
  • Colorectal cancer
  • Disease progression

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Investigation of c-myc oncogene amplification in colorectal cancer. / Kozma, L.; Kiss, I.; Szakáll, S.; Ember, I.

In: Cancer Letters, Vol. 81, No. 2, 30.06.1994, p. 165-169.

Research output: Contribution to journalArticle

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N2 - Tumour DNA samples of 20 patients with colorectal carcinoma were tested for c-myc amplification, using a quantitative dot-blot hybridization. Statistical analysis involving clinical and histological parameters like degree of differentiation, Dukes' stage, TNM staging system, age, sex and severity of disease, was applied to estimate the prognostic value of c-myc amplification. The amplification of the investigated oncogene - 1.61-fold on the average - was found to significantly correlate with the presence of distant metastasis (corr. coeff.: 0.506, P <0.05) and the severe course of the disease (corr. coeff.: 0.468, P <0.05). This result supports the hypothesis that tumour cells with c-myc amplification represent a more malignant and aggressive phenotype. It is also worth noting that both c-myc amplification and formation of distant metastasis are late events in the progression of colorectal cancer, which accounts for the more severe course of the disease.

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