Investigation of biotransformation capacity in patients with chronic liver diseases by pharmacokinetic methods: Experimental trials

T. Horvath, T. Past, Z. Tatai, A. Pár, I. Kádas, Z. Tapsonyi, T. Jávor

Research output: Contribution to journalArticle

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Abstract

The drug metabolizing capacity of patients with liver disease varies with the characteristics and the state of the disease. The aim of our studies on patients with various chronic liver diseases was to get information about the rational dosage for these patients. Our method in the first phase was antipyrine kinetics (hydroxylation), in the second phase sulfadimidine kinetics (acetylation) and menthol loading (glucuronidation). The induced state was investigated by D-glucaric acid excretion. Experimental trials: 1) comparison of groups of patients with moderate and severe liver diseases with each other, or with the normal control (two sample t test); 2) comparison of various groups of patients with each other and with the normal control (variance analysis); 3) research of potential correlation between the kinetic and biochemical parameters (correlation analysis); 4) reclassification studies with the use of kinetic and biochemical parameters (discrimination analysis). We discuss the practical advantage of the various experimental trials. The most important conclusion is that the reclassification by discrimination analysis gives important data to the economic planning of experiments.

Original languageEnglish
Pages (from-to)361-371
Number of pages11
JournalPolish Journal of Pharmacology and Pharmacy
Volume36
Issue number4
Publication statusPublished - 1984

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Biotransformation
Liver Diseases
Chronic Disease
Pharmacokinetics
Glucaric Acid
Sulfamethazine
Menthol
Antipyrine
Hydroxylation
Acetylation
Analysis of Variance
Economics
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Investigation of biotransformation capacity in patients with chronic liver diseases by pharmacokinetic methods : Experimental trials. / Horvath, T.; Past, T.; Tatai, Z.; Pár, A.; Kádas, I.; Tapsonyi, Z.; Jávor, T.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 36, No. 4, 1984, p. 361-371.

Research output: Contribution to journalArticle

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