Investigation of acidic pharmaceuticals in river water and sediment by microwave-assisted extraction and gas chromatography-mass spectrometry

Margit Varga, József Dobor, András Helenkár, Laura Jurecska, Jun Yao, G. Záray

Research output: Contribution to journalArticle

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Abstract

Investigations were performed along the Danube river at Budapest (Hungary) by collecting water and sediment samples simultaneously for 1 year in order to clarify the possible hazard of selected acidic pharmaceuticals (ibuprofen, naproxen, ketoprofen, and diclofenac) on the water supply used for the production of drinking water by bank filtration. In the case of water samples, the sample preparation procedure included solid phase extraction (SPE), meanwhile, in the case of sediment samples, microwave-assisted extraction (MAE) followed by dispersive matrix extraction (DME) for pre-cleaning as well as SPE for enrichment. The quantification was carried out using gas chromatography-mass spectrometry (GC-MS). The calculated recoveries were 97-99% (± 7%) for the water and 95-103% (± 12%) for the sediment samples. In the river water, ketoprofen concentration was always below the limit of quantification (LOQ) level; ibuprofen, naproxen and diclofenac could be quantified in the range of 8-50, 2-30, 7-90 ng/L. In sediments, only naproxen and diclofenac were found in the range of 2-20 and 5-38 ng/g, respectively. According to the obtained results, the concentration ratios of the two phases linearly depended on the total organic carbon content (TOC) of the sediments at each sampling date. The linear regressions were 0.925 and 0.946 for naproxen and diclofenac, respectively.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalMicrochemical Journal
Volume95
Issue number2
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Naproxen
Gas chromatography
Diclofenac
Mass spectrometry
Sediments
Rivers
Microwaves
Water
Ketoprofen
Pharmaceutical Preparations
Ibuprofen
Organic carbon
Water supply
Linear regression
Drinking Water
Cleaning
Hazards
Sampling
Recovery

Keywords

  • GC-MS
  • Microwave assisted extraction
  • Pharmaceutical residues
  • Sediment

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

Investigation of acidic pharmaceuticals in river water and sediment by microwave-assisted extraction and gas chromatography-mass spectrometry. / Varga, Margit; Dobor, József; Helenkár, András; Jurecska, Laura; Yao, Jun; Záray, G.

In: Microchemical Journal, Vol. 95, No. 2, 07.2010, p. 353-358.

Research output: Contribution to journalArticle

Varga, Margit ; Dobor, József ; Helenkár, András ; Jurecska, Laura ; Yao, Jun ; Záray, G. / Investigation of acidic pharmaceuticals in river water and sediment by microwave-assisted extraction and gas chromatography-mass spectrometry. In: Microchemical Journal. 2010 ; Vol. 95, No. 2. pp. 353-358.
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