Investigarea posibilitǎţii de a individualiza terapia cu aerosoli cu ajutorul modelului pulmonar stochastic.

Translated title of the contribution: Investigating the possibility of aerosol therapy individualization using the stochastic lung model

Klara Brâzaniuc, Z. Sárkány, Sanda Maria Copotoiu, M. Mǎruşteri, L. Azamfirei, Boér Kinga, I. Balásházy

Research output: Contribution to journalArticle

Abstract

The aim of our study is to examine the possibility of individualizing aerosol therapy, by determining the ideal diameter of the inhaled particles and the optimal breathing pattern, using a computerized simulation program. In order to find the optimal breathing pattern, we used different variations of the tidal volume and breathing period. We tried to determine the ideal particle diameter by carrying out a series of simulations for particles with diameters ranging from 1 to 10 microns. Our results show that increasing the particle diameter will lead to higher deposition values in the upper respiratory regions and bronchi, and smaller values in the acinary regions of the lung. Repeated simulations have led to two different ideal particle diameters, according to the localization of the desired effect. This way, for the bronchial regions the ideal particle diameter is 10 microns, and for the acinary regions 2 microns.

Original languageUndefined/Unknown
Pages (from-to)295-298
Number of pages4
JournalRevista medico-chirurgicalǎ̌ a Societǎ̌ţ&x031C;ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
Volume110
Issue number2
Publication statusPublished - Apr 2006

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Aerosols
Respiration
Lung
Tidal Volume
Bronchi
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Investigarea posibilitǎţii de a individualiza terapia cu aerosoli cu ajutorul modelului pulmonar stochastic. / Brâzaniuc, Klara; Sárkány, Z.; Copotoiu, Sanda Maria; Mǎruşteri, M.; Azamfirei, L.; Kinga, Boér; Balásházy, I.

In: Revista medico-chirurgicalǎ̌ a Societǎ̌ţ&x031C;ii de Medici ş̧i Naturaliş̧ti din Iaş̧i, Vol. 110, No. 2, 04.2006, p. 295-298.

Research output: Contribution to journalArticle

Brâzaniuc, Klara ; Sárkány, Z. ; Copotoiu, Sanda Maria ; Mǎruşteri, M. ; Azamfirei, L. ; Kinga, Boér ; Balásházy, I. / Investigarea posibilitǎţii de a individualiza terapia cu aerosoli cu ajutorul modelului pulmonar stochastic. In: Revista medico-chirurgicalǎ̌ a Societǎ̌ţ&x031C;ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 2006 ; Vol. 110, No. 2. pp. 295-298.
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