Inverse relation in the de novo arginase synthesis and nitric oxide production in murine and rat peritoneal macrophages in long-term cultures in vitro

A. Hrabák, ágnes Temesi, Ildikó Csuka, F. Antoni

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

1. 1. The de novo synthesis of arginase was much higher in murine than in rat peritoneal macrophages. This process was inhibited irreversibly by protein synthesis inhibitors and reversibly by glycolysis blockers. 2. 2. Rat macrophages produce more nitric oxide (NO) than murine cells. NO production was inhibited by the inhibitors of protein synthesis of glycolysis. 3. 3. The loading of macrophages by exogeneous arginine for 24 hr in vitro resulted in the increase of arginase and nitrite in macrophages to different extents. 4. 4. No great differences in lysozyme production was observed. 5. 5. The proportion of arginine taken up and incorporated is contrasted in murine and rat macrophages.

Original languageEnglish
Pages (from-to)839-845
Number of pages7
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume103
Issue number4
DOIs
Publication statusPublished - Dec 1992

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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