Inverse regulation of interleukin-6 (IL-6) and IL-6 receptor in histamine deficient histidine decarboxylase-knock-out mice

B. V. Horváth, A. Falus, S. Tóth, Cs Szalai, E. Lázár-Molnár, M. Cs Holub, E. Buzás, A. Nagy, A. K. Fulop

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Interleukin-6, a multifunctional cytokine upon binding to its receptor on hepatocytes regulates production of acute phase proteins involved in local and systemic inflammation. Gene expression and biosynthesis of IL-6 and its receptor (IL-6 R/gp130) is under complex regulation. Histamine, in addition to its principal role in immediate type hypersensitivity has been described to modulate IL-6 production and expression of IL-6 receptor. In this study, the IL-6 and IL-6 receptor expression was examined in histamine deficient histidine decarboxylase (HDC) knock-out mouse model. Our data suggest that in histamine deficient mice the inducibility of IL-6 is significantly reduced, whilst more IL-6 receptor/gp130 mRNA expresses in the liver than in wild type (HDC+/+) mice. These in vivo findings confirm earlier in vitro results and emphasize the efficacy of antihistamines in local IL-6 related processes.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalImmunology letters
Volume80
Issue number3
DOIs
Publication statusPublished - Mar 1 2002

Keywords

  • HDC
  • Histamine
  • IL-6
  • IL-6 receptor
  • Knock-out

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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