Inverse correlation between coronary blood flow velocity and sICAM-1 level observed in ischemic heart disease patients

Jusztina Bencze, Robert Gabor Kiss, Emese Toth-Zsamboki, Katarina Vargova, Gabor Kerecsen, Andras Korda, Ferenc Molnar, Istvan Preda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Systemic factors and blood flow velocity related to atherosclerosis have been examined mainly separately or by in vitro studies. The aim of our study was to investigate the association between local coronary blood flow (corrected TIMI frame count, CTFC) and systemic atherosclerosis-related inflammatory parameters such as soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (Il-6), high sensitivity C-reactive protein (hsCRP) and von Willebrand factor (vWF) in humans. We enrolled the following groups of ischemic heart disease (IHD) patients: patients with coronary stenosis and stable (CAD, n = 96) or unstable angina (ACS, n = 27), patients with documented myocardial ischemia and normal coronary angiogram (NEG, n = 68). Patient groups showed only marginal differences in CTFC or sICAM-1 levels. In contrast, when IHD patients were studied individually, general positive correlation was found between CTFC and sICAM-1 level (r = 0.33; in NEG r = 0.25; in CAD r = 0.37; in ACS r = 0.61), being the strongest in ACS. The relation was independent from age, gender, BMI, smoking, hypertension, diabetes, previous myocardial infarction, family history of IHD, medication, hsCRP, IL-6 and vWF levels. (odds ratio, OR = 6.4; CI 95%: 2.43-16.84; p < 0.05). Nevertheless, correlation between CTFC and IL-6, hsCRP, vWF levels was not found. These results indicate inverse correlation between coronary blood flow and adhesion molecule production independently from conventional cardiovascular risk factors and inflammatory markers.

Original languageEnglish
Pages (from-to)142-149
Number of pages8
JournalAtherosclerosis
Volume188
Issue number1
DOIs
Publication statusPublished - Sep 1 2006

Keywords

  • Coronary blood flow velocity
  • Corrected TIMI frame count
  • Endothelial dysfunction
  • Ischemic heart diseases
  • Soluble intercellular adhesion molecule-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Inverse correlation between coronary blood flow velocity and sICAM-1 level observed in ischemic heart disease patients'. Together they form a unique fingerprint.

  • Cite this