Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in cord blood lipids of full-term infants

T. Decsi, István Burus, Szilárd Molnár, Hajnalka Minda, Volker Veitl

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: Previous studies showed significant inverse correlations between values of trans isomeric and long-chain polyunsaturated fatty acids in plasma lipids of preterm infants and healthy children aged 1-15 y, Objective: We sought to evaluate the same correlations in fullterm infants at birth. Design: We studied healthy full-term infants (n = 42) born after normal pregnancies and deliveries. All infants had a family history of atopy (both parents or one of the parents and a sibling had atopic symptoms). The fatty acid composition of venous cord blood lipids was determined by high-resolution capillary gasliquid chromatography. Results: The mean (±SEM) sum of trans fatty acids was 0.49 ± 0.02% by wt in phospholipids, 2.47 ± 0.20% by wt in cholesterol esters, 1.73 ± 0.09% by wt in triacylglycerols, and 1.59 ± 0.07% by wt in nonesterified fatty acids. Linear correlation analysis showed significant inverse correlations between the sum of trans fatty acids and both arachidonic acid and docosahexaenoic acid in phospholipids (r = -0.56, P <0.001, and r = -0.48, P = 0.01, respectively), cholesterol esters (r = -0.52, P <0.001, and r = -0.39, P = 0.018, respectively), and nonesterified fatty acids (r = -0.41, P = 0.007, and r = -0.41, P = 0.006, respectively). Conclusion: Because trans fatty acids in the fetal circulation must originate from the maternal diet, our results indicate that maternal exposure to trans fatty acids may represent a previously neglected variable that inversely influences long-chain polyunsaturated fatty acid status in full-term infants at birth.

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume74
Issue number3
Publication statusPublished - 2001

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Trans Fatty Acids
long chain polyunsaturated fatty acids
trans fatty acids
Unsaturated Fatty Acids
Fetal Blood
blood lipids
Lipids
cholesteryl esters
Cholesterol Esters
Nonesterified Fatty Acids
free fatty acids
Phospholipids
phospholipids
Parents
Term Birth
atopy
Maternal Exposure
maternal nutrition
Docosahexaenoic Acids
docosahexaenoic acid

Keywords

  • Arachidonic acid
  • Cord blood
  • Docosahexaenoic acid
  • Full-term infant
  • Long-chain polyunsaturated fatty acid
  • Maternal diet
  • Maternal nutrition
  • Pregnancy
  • Prenatal nutrition
  • Trans fatty acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in cord blood lipids of full-term infants. / Decsi, T.; Burus, István; Molnár, Szilárd; Minda, Hajnalka; Veitl, Volker.

In: American Journal of Clinical Nutrition, Vol. 74, No. 3, 2001, p. 364-368.

Research output: Contribution to journalArticle

Decsi, T. ; Burus, István ; Molnár, Szilárd ; Minda, Hajnalka ; Veitl, Volker. / Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in cord blood lipids of full-term infants. In: American Journal of Clinical Nutrition. 2001 ; Vol. 74, No. 3. pp. 364-368.
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abstract = "Background: Previous studies showed significant inverse correlations between values of trans isomeric and long-chain polyunsaturated fatty acids in plasma lipids of preterm infants and healthy children aged 1-15 y, Objective: We sought to evaluate the same correlations in fullterm infants at birth. Design: We studied healthy full-term infants (n = 42) born after normal pregnancies and deliveries. All infants had a family history of atopy (both parents or one of the parents and a sibling had atopic symptoms). The fatty acid composition of venous cord blood lipids was determined by high-resolution capillary gasliquid chromatography. Results: The mean (±SEM) sum of trans fatty acids was 0.49 ± 0.02{\%} by wt in phospholipids, 2.47 ± 0.20{\%} by wt in cholesterol esters, 1.73 ± 0.09{\%} by wt in triacylglycerols, and 1.59 ± 0.07{\%} by wt in nonesterified fatty acids. Linear correlation analysis showed significant inverse correlations between the sum of trans fatty acids and both arachidonic acid and docosahexaenoic acid in phospholipids (r = -0.56, P <0.001, and r = -0.48, P = 0.01, respectively), cholesterol esters (r = -0.52, P <0.001, and r = -0.39, P = 0.018, respectively), and nonesterified fatty acids (r = -0.41, P = 0.007, and r = -0.41, P = 0.006, respectively). Conclusion: Because trans fatty acids in the fetal circulation must originate from the maternal diet, our results indicate that maternal exposure to trans fatty acids may represent a previously neglected variable that inversely influences long-chain polyunsaturated fatty acid status in full-term infants at birth.",
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T1 - Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in cord blood lipids of full-term infants

AU - Decsi, T.

AU - Burus, István

AU - Molnár, Szilárd

AU - Minda, Hajnalka

AU - Veitl, Volker

PY - 2001

Y1 - 2001

N2 - Background: Previous studies showed significant inverse correlations between values of trans isomeric and long-chain polyunsaturated fatty acids in plasma lipids of preterm infants and healthy children aged 1-15 y, Objective: We sought to evaluate the same correlations in fullterm infants at birth. Design: We studied healthy full-term infants (n = 42) born after normal pregnancies and deliveries. All infants had a family history of atopy (both parents or one of the parents and a sibling had atopic symptoms). The fatty acid composition of venous cord blood lipids was determined by high-resolution capillary gasliquid chromatography. Results: The mean (±SEM) sum of trans fatty acids was 0.49 ± 0.02% by wt in phospholipids, 2.47 ± 0.20% by wt in cholesterol esters, 1.73 ± 0.09% by wt in triacylglycerols, and 1.59 ± 0.07% by wt in nonesterified fatty acids. Linear correlation analysis showed significant inverse correlations between the sum of trans fatty acids and both arachidonic acid and docosahexaenoic acid in phospholipids (r = -0.56, P <0.001, and r = -0.48, P = 0.01, respectively), cholesterol esters (r = -0.52, P <0.001, and r = -0.39, P = 0.018, respectively), and nonesterified fatty acids (r = -0.41, P = 0.007, and r = -0.41, P = 0.006, respectively). Conclusion: Because trans fatty acids in the fetal circulation must originate from the maternal diet, our results indicate that maternal exposure to trans fatty acids may represent a previously neglected variable that inversely influences long-chain polyunsaturated fatty acid status in full-term infants at birth.

AB - Background: Previous studies showed significant inverse correlations between values of trans isomeric and long-chain polyunsaturated fatty acids in plasma lipids of preterm infants and healthy children aged 1-15 y, Objective: We sought to evaluate the same correlations in fullterm infants at birth. Design: We studied healthy full-term infants (n = 42) born after normal pregnancies and deliveries. All infants had a family history of atopy (both parents or one of the parents and a sibling had atopic symptoms). The fatty acid composition of venous cord blood lipids was determined by high-resolution capillary gasliquid chromatography. Results: The mean (±SEM) sum of trans fatty acids was 0.49 ± 0.02% by wt in phospholipids, 2.47 ± 0.20% by wt in cholesterol esters, 1.73 ± 0.09% by wt in triacylglycerols, and 1.59 ± 0.07% by wt in nonesterified fatty acids. Linear correlation analysis showed significant inverse correlations between the sum of trans fatty acids and both arachidonic acid and docosahexaenoic acid in phospholipids (r = -0.56, P <0.001, and r = -0.48, P = 0.01, respectively), cholesterol esters (r = -0.52, P <0.001, and r = -0.39, P = 0.018, respectively), and nonesterified fatty acids (r = -0.41, P = 0.007, and r = -0.41, P = 0.006, respectively). Conclusion: Because trans fatty acids in the fetal circulation must originate from the maternal diet, our results indicate that maternal exposure to trans fatty acids may represent a previously neglected variable that inversely influences long-chain polyunsaturated fatty acid status in full-term infants at birth.

KW - Arachidonic acid

KW - Cord blood

KW - Docosahexaenoic acid

KW - Full-term infant

KW - Long-chain polyunsaturated fatty acid

KW - Maternal diet

KW - Maternal nutrition

KW - Pregnancy

KW - Prenatal nutrition

KW - Trans fatty acid

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M3 - Article

VL - 74

SP - 364

EP - 368

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

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