Invasive lobular carcinoma with extracellular mucin production—a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases

G. Cserni, Giuseppe Floris, Nektarios Koufopoulos, Anikó Kovács, Afroditi Nonni, Peter Regitnig, Anders Stahls, Zsuzsanna Varga

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Invasive lobular carcinoma of the breast is known to produce intracellular mucin and has been recognized in single-case reports to show extracellular mucin production, as well. This latter morphology is not only rare but must also be under- or misdiagnosed. The aim was to better characterize this entity. Cases of lobular cancers demonstrating extracellular mucin formation were identified in a multi-institutional effort and their clinical and morphologic features were assessed. Immunohistochemistry was used to characterize the E-cadherin-membrane complex, neuroendocrine differentiation, and to some extent, mucin formation. All but one of the eight cases occurred in postmenopausal patients. Extracellular mucin production was present in 5 to 50% of the tumour samples and rarely also appeared in nodal and distant metastases. The tumours were completely E-cadherin negative and showed cytoplasmic p120 positivity. The majority (n = 6/8) was also completely negative for β-catenin, but two tumours displayed focal β-catenin positivity in the mucinous area. MUC1 and MUC2 expression was observed in all and 7/8 tumours, respectively; neuroendocrine differentiation was present in only one. Invasive lobular carcinoma with extracellular mucin formation is a rare morphologic variant of lobular carcinoma prone to be misdiagnosed and warranting further studies.

Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalVirchows Archiv
Volume471
Issue number1
DOIs
Publication statusPublished - Jul 1 2017

Fingerprint

Lobular Carcinoma
Mucins
Breast
Catenins
Cadherins
Neoplasms
Diagnostic Errors
Immunohistochemistry
Neoplasm Metastasis
Membranes

Keywords

  • Breast cancer
  • E-cadherin
  • Extracellular mucin
  • Lobular carcinoma
  • Mucinous carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Invasive lobular carcinoma with extracellular mucin production—a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases. / Cserni, G.; Floris, Giuseppe; Koufopoulos, Nektarios; Kovács, Anikó; Nonni, Afroditi; Regitnig, Peter; Stahls, Anders; Varga, Zsuzsanna.

In: Virchows Archiv, Vol. 471, No. 1, 01.07.2017, p. 3-12.

Research output: Contribution to journalArticle

Cserni, G. ; Floris, Giuseppe ; Koufopoulos, Nektarios ; Kovács, Anikó ; Nonni, Afroditi ; Regitnig, Peter ; Stahls, Anders ; Varga, Zsuzsanna. / Invasive lobular carcinoma with extracellular mucin production—a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases. In: Virchows Archiv. 2017 ; Vol. 471, No. 1. pp. 3-12.
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