Invasive coronary procedures activate the complement system

Zsófia Horváth, Dorottya Csuka, Katarina Vargova, Andrea Kovács, Sarolta Leé, Lilian Varga, István Préda, George Füst, Zoltán Prohászka, Róbert Gábor Kiss

Research output: Contribution to journalArticle

Abstract

Objective: To examine the mechanism of complement system activation after percutaneous coronary intervention (PCI) performed in stable angina. Methods: We enrolled 76 stable angina (SAP) patients scheduled for elective coronary angiography. The effect of PCI and coronary stent implantation was studied on twenty- four SAP patients (PCI group). Twenty-seven patients with positive coronary angiography (but without PCI) and 25 patients with negative coronary angiography served as controls (PC and NC group, respectively). In each individual, the plasma levels of several complement activation products - C1rC1sC1inh, C3bBbP, and SC5b-9 - were measured on admission, 6 and 24 hours after coronary angiography/ or PCI. Results: Significant increase (p<0.01 for all comparisons) of plasma C3bBbP levels - as the activation product of alternative pathway - was observed six hours after PCI, or coronary angiography and returned to baseline after 24 hours. Conclusions: Both elective PCI and coronary angiography lead to temporary activation of the complement system through the alternative pathway.

Original languageEnglish
Pages (from-to)228-237
Number of pages10
JournalExperimental and Clinical Cardiology
Volume20
Issue number1
Publication statusPublished - 2014

Keywords

  • Alternative pathway of complement activation
  • C3bBbP
  • Complement system
  • Coronary angiography
  • Percutaneous coronary intervention
  • Stable angina

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Invasive coronary procedures activate the complement system'. Together they form a unique fingerprint.

  • Cite this