Invasion from a cell aggregate - The roles of active cell motion and mechanical equilibrium

A. Czirók, A. Szabó, K. Varga, T. Garay, B. Hegedűs, A. Szabó, K. Varga, T. Garay, B. Hegeds

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Cell invasion from an aggregate into a surrounding extracellular matrix (ECM) is an important process during development disease, e.g., vascular network assembly or tumor progression. To describe the behavior emerging from autonomous cell motility, cell-cell adhesion and contact guidance by ECM filaments, we propose a suitably modified cellular Potts model. We consider an active cell motility process in which internal polarity is governed by a positive feedback from cell displacements, a mechanism that can result in highly persistent motion when constrained by an oriented ECM structure. The model allows us to explore the interplay between haptotaxis, matrix degradation and active cell movement. We show that for certain conditions the cells are able to both invade the ECM and follow the ECM tracks. Furthermore, we argue that enforcing mechanical equilibrium within a bulk cell mass is of key importance in multicellular simulations.

Original languageEnglish
Article number016010
JournalPhysical Biology
Volume9
Issue number1
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Extracellular Matrix
Cell Movement
Chemotaxis
Vascular Diseases
Cell Adhesion
Neoplasms

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Structural Biology

Cite this

Invasion from a cell aggregate - The roles of active cell motion and mechanical equilibrium. / Czirók, A.; Szabó, A.; Varga, K.; Garay, T.; Hegedűs, B.; Szabó, A.; Varga, K.; Garay, T.; Hegeds, B.

In: Physical Biology, Vol. 9, No. 1, 016010, 02.2012.

Research output: Contribution to journalArticle

Czirók, A. ; Szabó, A. ; Varga, K. ; Garay, T. ; Hegedűs, B. ; Szabó, A. ; Varga, K. ; Garay, T. ; Hegeds, B. / Invasion from a cell aggregate - The roles of active cell motion and mechanical equilibrium. In: Physical Biology. 2012 ; Vol. 9, No. 1.
@article{ab8f9783b96c46cdb6a1b900cfc2d94b,
title = "Invasion from a cell aggregate - The roles of active cell motion and mechanical equilibrium",
abstract = "Cell invasion from an aggregate into a surrounding extracellular matrix (ECM) is an important process during development disease, e.g., vascular network assembly or tumor progression. To describe the behavior emerging from autonomous cell motility, cell-cell adhesion and contact guidance by ECM filaments, we propose a suitably modified cellular Potts model. We consider an active cell motility process in which internal polarity is governed by a positive feedback from cell displacements, a mechanism that can result in highly persistent motion when constrained by an oriented ECM structure. The model allows us to explore the interplay between haptotaxis, matrix degradation and active cell movement. We show that for certain conditions the cells are able to both invade the ECM and follow the ECM tracks. Furthermore, we argue that enforcing mechanical equilibrium within a bulk cell mass is of key importance in multicellular simulations.",
author = "A. Czir{\'o}k and A. Szab{\'o} and K. Varga and T. Garay and B. Hegedűs and A. Szab{\'o} and K. Varga and T. Garay and B. Hegeds",
year = "2012",
month = "2",
doi = "10.1088/1478-3975/9/1/016010",
language = "English",
volume = "9",
journal = "Physical Biology",
issn = "1478-3967",
publisher = "IOP Publishing Ltd.",
number = "1",

}

TY - JOUR

T1 - Invasion from a cell aggregate - The roles of active cell motion and mechanical equilibrium

AU - Czirók, A.

AU - Szabó, A.

AU - Varga, K.

AU - Garay, T.

AU - Hegedűs, B.

AU - Szabó, A.

AU - Varga, K.

AU - Garay, T.

AU - Hegeds, B.

PY - 2012/2

Y1 - 2012/2

N2 - Cell invasion from an aggregate into a surrounding extracellular matrix (ECM) is an important process during development disease, e.g., vascular network assembly or tumor progression. To describe the behavior emerging from autonomous cell motility, cell-cell adhesion and contact guidance by ECM filaments, we propose a suitably modified cellular Potts model. We consider an active cell motility process in which internal polarity is governed by a positive feedback from cell displacements, a mechanism that can result in highly persistent motion when constrained by an oriented ECM structure. The model allows us to explore the interplay between haptotaxis, matrix degradation and active cell movement. We show that for certain conditions the cells are able to both invade the ECM and follow the ECM tracks. Furthermore, we argue that enforcing mechanical equilibrium within a bulk cell mass is of key importance in multicellular simulations.

AB - Cell invasion from an aggregate into a surrounding extracellular matrix (ECM) is an important process during development disease, e.g., vascular network assembly or tumor progression. To describe the behavior emerging from autonomous cell motility, cell-cell adhesion and contact guidance by ECM filaments, we propose a suitably modified cellular Potts model. We consider an active cell motility process in which internal polarity is governed by a positive feedback from cell displacements, a mechanism that can result in highly persistent motion when constrained by an oriented ECM structure. The model allows us to explore the interplay between haptotaxis, matrix degradation and active cell movement. We show that for certain conditions the cells are able to both invade the ECM and follow the ECM tracks. Furthermore, we argue that enforcing mechanical equilibrium within a bulk cell mass is of key importance in multicellular simulations.

UR - http://www.scopus.com/inward/record.url?scp=84856972051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856972051&partnerID=8YFLogxK

U2 - 10.1088/1478-3975/9/1/016010

DO - 10.1088/1478-3975/9/1/016010

M3 - Article

C2 - 22313673

AN - SCOPUS:84856972051

VL - 9

JO - Physical Biology

JF - Physical Biology

SN - 1478-3967

IS - 1

M1 - 016010

ER -