Invariant Vα7.2-Jα33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells

Agnes Peterfalvi, Eva Gomori, Tamas Magyarlaki, Jozsef Pal, Miklos Banati, Andras Javorhazy, Julia Szekeres-Bartho, Laszlo Szereday, Zsolt Illes

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The anti-tumor response of human invariant NKT (NKT) cells is well established. A novel T cell subset, mucosal-associated invariant T (MAIT) cells, possesses similar regulatory properties to NKT cells in autoimmune models and disease. Here, we examined the clonality of four T cell subsets expressing invariant αTCR, including Vα7.2-Jα33 of MAIT cells, in 19 kidney and brain tumors. The MAIT clonotype was identified and co-expressed with NKT clonotype in half of the tumors. In contrast, two other invariant T cell clonotypes (Vα4 and Vα19) were not present in tumors. Such tumors also expressed Vβ2 and Vβ13, the restricted TCRβ chain of MAIT cells and the antigen-presenting molecule MR1. A high percentage of infiltrating T cells was CD8+ and expressed HLA-DR suggesting activation. Although the MAIT αTCR was identified in both peripheral CD56+ and CD56- subsets, infiltrating lymphocytes were CD56 negative. The clonal presence of MAIT cells in tumors correlated with the expression of pro-inflammatory cytokines but no IL-4, IL-5 and IL-10, suggesting that a pro-inflammatory subset of human MAIT cells may exist. Our data imply that a CD56- subset of MAIT cells may participate in tumor immune responses similarly to NKT cells.

Original languageEnglish
Pages (from-to)1517-1525
Number of pages9
JournalInternational Immunology
Volume20
Issue number12
DOIs
Publication statusPublished - Dec 8 2008

Keywords

  • Innate
  • Invariant TCR
  • MAIT
  • NKT
  • Tumor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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