Intrinsically disordered proteins: Emerging interaction specialists

Peter Tompa, Eva Schad, Agnes Tantos, Lajos Kalmar

Research output: Contribution to journalReview article

109 Citations (Scopus)

Abstract

Intrinsically disordered proteins or regions of proteins (IDPs/IDRs) most often function through protein-protein interactions, when they permanently or transiently bind partner molecules with diverse functional consequences. There is a rapid advance in our understanding of the ensuing functional modes, obtained from describing atomic details of individual complexes, proteome-wide studies of interactomes and characterizing loosely assembled hydrogels and tightly packed amyloids. Here we briefly survey the most important recent methodological developments and structural-functional observations, with the aim of increasing the general appreciation of IDPs/IDRs as 'interaction specialists'.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalCurrent Opinion in Structural Biology
Volume35
DOIs
Publication statusPublished - Dec 1 2015

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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