Intravenous lnterleukin-1 -Beta-Induced Inhibition of Gastric Emptying: Involvement of Central Corticotrophin-Releasing Factor and Prostaglandin Pathways in Rats

G. Sütõ, A. Király, V. Plourde, Yvette Taché

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The role of corticotrophin-releasing factor (CRF) and prostaglandin in interleukin-1Β (IL-1Β)-induced delayed gastric emptying was investigated. Gastric emptying was monitored 20 min after orogastric delivery of a methylcellulose phenol red solution in fasted rats injected intravenously with IL-1Β at the ED50 dose (3 ng/rat) 30 min before the non-caloric solution. The IL-1 receptor antagonist (IL-1ra) injected intravenously (3 μg/rat) or intracisternally (100 ng/rat) reversed the IL-1Β-induced 47% inhibition of gastric emptying by 100% and 62%, respectively. The new CRF antagonist [DPhe12, Nle21 > 38, CαMeLeu37]-CRF12-41 (20 μg/rat), injected intracisternally, or indomethacin (5 mg/kg i.p.) completely abolished IL-1Β (3 ng/rat i.v.)-induced gastric stasis. The CRF antagonist injected intravenously (20 μg/rat) did not influence the IL-1Β inhibitory action. None of the pretreatments given alone influenced basal gastric emptying. These data suggest that peripheral IL-1Β-induced inhibition of gastric emptying is mediated by specific IL-1 receptor interactions and brain CRF pathways requiring the integrity of eicosanoid-cyclooxygenase pathways.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
Issue number2
Publication statusPublished - Jan 1 1996



  • Antagonist
  • CRF
  • Corticotrophin-releasing factor
  • Gastric emptying
  • Interleukin-1-beta
  • Interleukin-receptor antagonist
  • Prostaglandin

ASJC Scopus subject areas

  • Gastroenterology

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