Intravenous interleukin-1-beta-induced inhibition of gastric emptying: Involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats

G. Sütö, Á Kiraly, V. Plourde, Y. Taché

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

The role of corticotrophin-releasing factor (CRF) and prostaglandin in interleukin-1β (IL-1β)-induced delayed gastric emptying was investigated. Gastric emptying was monitored 20 min after orogastric delivery of a methylcellulose phenol red solution in fasted rats injected intravenously with IL-1β at the ED50 dose (3 ng/rat) 30 min before the non-caloric solution. The IL-1 receptor antagonist (IL-1ra) injected intravenously (3 μg/rat) or intracisternally (100 ng/rat) reversed the IL-1β-induced 47% inhibition of gastric emptying by 100% and 62%, respectively. The new CRF antagonist [DPhe12, Nle21,38, C(α)MeLeu37]-CRF12-41 (20 μg/rat), injected intracisternally, or indomethacin (5 mg/kg i.p.) completely abolished IL-1β (3 ng/rat i.v.)-induced gastric stasis. The CRF antagonist injected intravenously (20 μg/rat) did not influence the IL-1β inhibitory action. None of the pretreatments given alone influenced basal gastric emptying. These data suggest that peripheral IL-1β-induced inhibition of gastric emptying is mediated by specific IL-1 receptor interactions and brain CRF pathways requiring the integrity of eicosanoid-cyclooxygenase pathways.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalDigestion
Volume57
Issue number2
Publication statusPublished - Mar 1996

Fingerprint

Gastric Emptying
Corticotropin-Releasing Hormone
Interleukin-1beta
Prostaglandins
Interleukin-1
Interleukin-1 Receptors
Phenolsulfonphthalein
Gastroparesis
Methylcellulose
Eicosanoids
Interleukin-3
Prostaglandin-Endoperoxide Synthases
Indomethacin
Brain

Keywords

  • Antagonist, CRF
  • Corticotrophin-releasing factor
  • Gastric emptying
  • Interleukin-1-beta
  • Interleukin-receptor antagonist
  • Prostaglandin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Intravenous interleukin-1-beta-induced inhibition of gastric emptying : Involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats. / Sütö, G.; Kiraly, Á; Plourde, V.; Taché, Y.

In: Digestion, Vol. 57, No. 2, 03.1996, p. 135-140.

Research output: Contribution to journal › Article

Sütö, G, Kiraly, Á, Plourde, V & Taché, Y 1996, 'Intravenous interleukin-1-beta-induced inhibition of gastric emptying: Involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats', Digestion, vol. 57, no. 2, pp. 135-140.
Sütö G, Kiraly Á, Plourde V, Taché Y. Intravenous interleukin-1-beta-induced inhibition of gastric emptying: Involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats. Digestion. 1996 Mar;57(2):135-140.
Sütö, G. ; Kiraly, Á ; Plourde, V. ; Taché, Y. / Intravenous interleukin-1-beta-induced inhibition of gastric emptying : Involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats. In: Digestion. 1996 ; Vol. 57, No. 2. pp. 135-140.
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