Az immunpatológiai hátteru habituális vetélés kezelése terhesség alatti intravénás immunglobulinnal

Translated title of the contribution: Intravenous immunoglobulin treatment of recurrent spontaneous abortion with immunopathological background

József Bátorfi, Beatrix Kotlán, Ágnes Padányi, Mariann Réti, Éva Gýodi, K. Rajczy, Katalin Miklós, Julianna Németh, Ferenc Melicher, István Vályi-Nagy, G. Petrányi, V. Fülöp

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow each other typically in the first trimester. The root cause of miscarriages often can not be found. A significant proportion of this unexplained RSA cases may be caused by immunopathological failure. Aim: A multicentric clinical study started in 2000 to introduce an immunological screening protocol for patients suffering in idiopathic habitual abortion, and to use immunotherapy for their treatment if immunological background was defined. Method: The general checkup of the patients was managed based upon a detailed protocol, with which non-immunopathological reasons for RSA were excluded. The unexplained RSA cases underwent an immunological checkup including cellular and humoral immunological, immunogenetical and autoimmun examinations. Based upon these parameters, the immunopathological background of RSA was certified or excluded. In the confirmed immunopathological cases intravenous immunoglobulin (IVIG) therapy was applied during their next pregnancy, with continuous monitoring of the immunological parameters. Results: 120 patients with RSA were examined, and 32 of them got IVIG therapy during their next pregnancy. In 72% of cases (23/32) IVIG treatment for RSA with immunopathological alloimmune background was successful, with the outcome of healthy newborn. Of the 9 unsuccesful cases, in 6 patients subsequently additional non-immunopathological reasons were diagnosed for their RSA. IVIG treatment of patients with clear alloimmune background was successful in 88,5% (23/26). Conclusion: Results show that immunopathological checkup and immunotherapy is a useful treatment in the modern medicine for the patients with unexplained RSA. However the success of this method depends on the adherence of the checkup protocol, because unsuccessful therapy of non-clear cases can reduce the efficiency.

Original languageHungarian
Pages (from-to)2297-2302
Number of pages6
JournalOrvosi Hetilap
Volume146
Issue number45
Publication statusPublished - 2005

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Habitual Abortion
Intravenous Immunoglobulins
Spontaneous Abortion
Therapeutics
Passive Immunization
Immunotherapy
Immunologic Monitoring
Pregnancy
Modern 1601-history
First Pregnancy Trimester
Newborn Infant

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az immunpatológiai hátteru habituális vetélés kezelése terhesség alatti intravénás immunglobulinnal. / Bátorfi, József; Kotlán, Beatrix; Padányi, Ágnes; Réti, Mariann; Gýodi, Éva; Rajczy, K.; Miklós, Katalin; Németh, Julianna; Melicher, Ferenc; Vályi-Nagy, István; Petrányi, G.; Fülöp, V.

In: Orvosi Hetilap, Vol. 146, No. 45, 2005, p. 2297-2302.

Research output: Contribution to journalArticle

Bátorfi, J, Kotlán, B, Padányi, Á, Réti, M, Gýodi, É, Rajczy, K, Miklós, K, Németh, J, Melicher, F, Vályi-Nagy, I, Petrányi, G & Fülöp, V 2005, 'Az immunpatológiai hátteru habituális vetélés kezelése terhesség alatti intravénás immunglobulinnal', Orvosi Hetilap, vol. 146, no. 45, pp. 2297-2302.
Bátorfi J, Kotlán B, Padányi Á, Réti M, Gýodi É, Rajczy K et al. Az immunpatológiai hátteru habituális vetélés kezelése terhesség alatti intravénás immunglobulinnal. Orvosi Hetilap. 2005;146(45):2297-2302.
Bátorfi, József ; Kotlán, Beatrix ; Padányi, Ágnes ; Réti, Mariann ; Gýodi, Éva ; Rajczy, K. ; Miklós, Katalin ; Németh, Julianna ; Melicher, Ferenc ; Vályi-Nagy, István ; Petrányi, G. ; Fülöp, V. / Az immunpatológiai hátteru habituális vetélés kezelése terhesség alatti intravénás immunglobulinnal. In: Orvosi Hetilap. 2005 ; Vol. 146, No. 45. pp. 2297-2302.
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abstract = "Introduction: Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow each other typically in the first trimester. The root cause of miscarriages often can not be found. A significant proportion of this unexplained RSA cases may be caused by immunopathological failure. Aim: A multicentric clinical study started in 2000 to introduce an immunological screening protocol for patients suffering in idiopathic habitual abortion, and to use immunotherapy for their treatment if immunological background was defined. Method: The general checkup of the patients was managed based upon a detailed protocol, with which non-immunopathological reasons for RSA were excluded. The unexplained RSA cases underwent an immunological checkup including cellular and humoral immunological, immunogenetical and autoimmun examinations. Based upon these parameters, the immunopathological background of RSA was certified or excluded. In the confirmed immunopathological cases intravenous immunoglobulin (IVIG) therapy was applied during their next pregnancy, with continuous monitoring of the immunological parameters. Results: 120 patients with RSA were examined, and 32 of them got IVIG therapy during their next pregnancy. In 72{\%} of cases (23/32) IVIG treatment for RSA with immunopathological alloimmune background was successful, with the outcome of healthy newborn. Of the 9 unsuccesful cases, in 6 patients subsequently additional non-immunopathological reasons were diagnosed for their RSA. IVIG treatment of patients with clear alloimmune background was successful in 88,5{\%} (23/26). Conclusion: Results show that immunopathological checkup and immunotherapy is a useful treatment in the modern medicine for the patients with unexplained RSA. However the success of this method depends on the adherence of the checkup protocol, because unsuccessful therapy of non-clear cases can reduce the efficiency.",
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T1 - Az immunpatológiai hátteru habituális vetélés kezelése terhesség alatti intravénás immunglobulinnal

AU - Bátorfi, József

AU - Kotlán, Beatrix

AU - Padányi, Ágnes

AU - Réti, Mariann

AU - Gýodi, Éva

AU - Rajczy, K.

AU - Miklós, Katalin

AU - Németh, Julianna

AU - Melicher, Ferenc

AU - Vályi-Nagy, István

AU - Petrányi, G.

AU - Fülöp, V.

PY - 2005

Y1 - 2005

N2 - Introduction: Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow each other typically in the first trimester. The root cause of miscarriages often can not be found. A significant proportion of this unexplained RSA cases may be caused by immunopathological failure. Aim: A multicentric clinical study started in 2000 to introduce an immunological screening protocol for patients suffering in idiopathic habitual abortion, and to use immunotherapy for their treatment if immunological background was defined. Method: The general checkup of the patients was managed based upon a detailed protocol, with which non-immunopathological reasons for RSA were excluded. The unexplained RSA cases underwent an immunological checkup including cellular and humoral immunological, immunogenetical and autoimmun examinations. Based upon these parameters, the immunopathological background of RSA was certified or excluded. In the confirmed immunopathological cases intravenous immunoglobulin (IVIG) therapy was applied during their next pregnancy, with continuous monitoring of the immunological parameters. Results: 120 patients with RSA were examined, and 32 of them got IVIG therapy during their next pregnancy. In 72% of cases (23/32) IVIG treatment for RSA with immunopathological alloimmune background was successful, with the outcome of healthy newborn. Of the 9 unsuccesful cases, in 6 patients subsequently additional non-immunopathological reasons were diagnosed for their RSA. IVIG treatment of patients with clear alloimmune background was successful in 88,5% (23/26). Conclusion: Results show that immunopathological checkup and immunotherapy is a useful treatment in the modern medicine for the patients with unexplained RSA. However the success of this method depends on the adherence of the checkup protocol, because unsuccessful therapy of non-clear cases can reduce the efficiency.

AB - Introduction: Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow each other typically in the first trimester. The root cause of miscarriages often can not be found. A significant proportion of this unexplained RSA cases may be caused by immunopathological failure. Aim: A multicentric clinical study started in 2000 to introduce an immunological screening protocol for patients suffering in idiopathic habitual abortion, and to use immunotherapy for their treatment if immunological background was defined. Method: The general checkup of the patients was managed based upon a detailed protocol, with which non-immunopathological reasons for RSA were excluded. The unexplained RSA cases underwent an immunological checkup including cellular and humoral immunological, immunogenetical and autoimmun examinations. Based upon these parameters, the immunopathological background of RSA was certified or excluded. In the confirmed immunopathological cases intravenous immunoglobulin (IVIG) therapy was applied during their next pregnancy, with continuous monitoring of the immunological parameters. Results: 120 patients with RSA were examined, and 32 of them got IVIG therapy during their next pregnancy. In 72% of cases (23/32) IVIG treatment for RSA with immunopathological alloimmune background was successful, with the outcome of healthy newborn. Of the 9 unsuccesful cases, in 6 patients subsequently additional non-immunopathological reasons were diagnosed for their RSA. IVIG treatment of patients with clear alloimmune background was successful in 88,5% (23/26). Conclusion: Results show that immunopathological checkup and immunotherapy is a useful treatment in the modern medicine for the patients with unexplained RSA. However the success of this method depends on the adherence of the checkup protocol, because unsuccessful therapy of non-clear cases can reduce the efficiency.

KW - Immunoglobulin

KW - Recurrent spontaneous abortion

KW - Reproductive immunology

KW - RSA

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