Intrathoracic solitary fibrous tumor-an international multicenter study on clinical outcome and novel circulating biomarkers

Bahil Ghanim, Sebastian Hess, Pietro Bertoglio, Ali Celik, Aynur Bas, Felicitas Oberndorfer, Franca Melfi, Alfredo Mussi, Walter Klepetko, Christine Pirker, Walter Berger, Imrich Harmati, Attila Farkas, Hendrik Jan Ankersmit, B. Döme, Janos Fillinger, Clemens Aigner, B. Hegedűs, Ferenc Renyi-Vamos, György Lang

Research output: Contribution to journalArticle

Abstract

Intrathoracic solitary fibrous tumor (SFT) is a rare disease. Radical resection is the standard of care. However, estimating prognosis and planning follow-up and treatment strategies remains challenging. Data were retrospectively collected by five international centers to explore outcome and biomarkers for predicting event-free-survival (EFS). 125 histological proven SFT patients (74 female; 59.2%; 104 benign; 83.2%) were analyzed. The one-, three-, five-and ten-year EFS after curative-intent surgery was 98%, 90%, 77% and 67%, respectively. Patients age (≥59 vs. <59 years hazard ratio (HR) 4.23, 95 confidence interval (CI) 1.56-11.47, p = 0.005), tumor-dignity (malignant vs. benign HR 6.98, CI 3.01-16.20, p <0.001), tumor-size (>10 cm vs. ≤10 cm HR 2.53, CI 1.10-5.83, p = 0.030), de Perrot staging (late vs. early HR 3.85, CI 1.65-8.98, p = 0.002) and resection margins (positive vs. negative HR 4.17, CI 1.15-15.17, p = 0,030) were associated with EFS. Furthermore, fibrinogen (elevated vs. normal HR 4.00, CI 1.49-10.72, p = 0.006) and the neutrophil-to-lymphocyte-ratio (NLR > 5 vs. < 5 HR 3.91, CI 1.40-10.89, p = 0.009) were prognostic after univariate analyses. After multivariate analyses tumor-dignity and fibrinogen remained as independent prognosticators. Besides validating the role of age, tumor-dignity, tumor-size, stage and resection margins, we identified for the first time inflammatory markers as prognosticators in SFT.

Original languageEnglish
Article number12557
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Solitary Fibrous Tumors
Multicenter Studies
Disease-Free Survival
Biomarkers
Fibrinogen
Neoplasms
Standard of Care
Rare Diseases
Neutrophils
Multivariate Analysis
Lymphocytes
Margins of Excision
Therapeutics

ASJC Scopus subject areas

  • General

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Intrathoracic solitary fibrous tumor-an international multicenter study on clinical outcome and novel circulating biomarkers. / Ghanim, Bahil; Hess, Sebastian; Bertoglio, Pietro; Celik, Ali; Bas, Aynur; Oberndorfer, Felicitas; Melfi, Franca; Mussi, Alfredo; Klepetko, Walter; Pirker, Christine; Berger, Walter; Harmati, Imrich; Farkas, Attila; Jan Ankersmit, Hendrik; Döme, B.; Fillinger, Janos; Aigner, Clemens; Hegedűs, B.; Renyi-Vamos, Ferenc; Lang, György.

In: Scientific Reports, Vol. 7, No. 1, 12557, 01.12.2017.

Research output: Contribution to journalArticle

Ghanim, B, Hess, S, Bertoglio, P, Celik, A, Bas, A, Oberndorfer, F, Melfi, F, Mussi, A, Klepetko, W, Pirker, C, Berger, W, Harmati, I, Farkas, A, Jan Ankersmit, H, Döme, B, Fillinger, J, Aigner, C, Hegedűs, B, Renyi-Vamos, F & Lang, G 2017, 'Intrathoracic solitary fibrous tumor-an international multicenter study on clinical outcome and novel circulating biomarkers', Scientific Reports, vol. 7, no. 1, 12557. https://doi.org/10.1038/s41598-017-12914-2
Ghanim, Bahil ; Hess, Sebastian ; Bertoglio, Pietro ; Celik, Ali ; Bas, Aynur ; Oberndorfer, Felicitas ; Melfi, Franca ; Mussi, Alfredo ; Klepetko, Walter ; Pirker, Christine ; Berger, Walter ; Harmati, Imrich ; Farkas, Attila ; Jan Ankersmit, Hendrik ; Döme, B. ; Fillinger, Janos ; Aigner, Clemens ; Hegedűs, B. ; Renyi-Vamos, Ferenc ; Lang, György. / Intrathoracic solitary fibrous tumor-an international multicenter study on clinical outcome and novel circulating biomarkers. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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AU - Oberndorfer, Felicitas

AU - Melfi, Franca

AU - Mussi, Alfredo

AU - Klepetko, Walter

AU - Pirker, Christine

AU - Berger, Walter

AU - Harmati, Imrich

AU - Farkas, Attila

AU - Jan Ankersmit, Hendrik

AU - Döme, B.

AU - Fillinger, Janos

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