Intraoperative and postoperative corneal thickness change after collagen crosslinking therapy

Ziad Hassan, Laszlo Modis, Eszter Szalai, Andras Berta, Gabor Nemeth

Research output: Contribution to journalArticle

10 Citations (Scopus)


Purpose: To assess intraoperative and postoperative changes in corneal thickness subsequent to riboflavin-UVA (collagen crosslinking [CXL]) treatment. Methods: Forty-one eyes of 41 patients (mean age 27.97 ± 6.97 years) were treated with CXL technique. During treatment, isotonic riboflavin was instilled and corneal thickness measurements were obtained at the cornea apex, the thinnest point, and the pupil center at 15 and 30 minutes, then 3 days, 1 week, and 1, 3, 6, and 12 months after surgery using Pentacam HR and an ultrasound pachymeter. Results: A decrease in corneal thickness was detected 15 minutes intraoperatively with a value of 108.95 ± 48.6 μm, and 112.35 ± 47.3 μm at 30 minutes (p<0.001). Three days after the operation, no deviation was found from the initial values (p = 0.17). No further changes were detected during the follow-up period. Conclusions: Isotonic riboflavin solution used during CXL treatment resulted in a significant decrease in corneal thickness, but its effect had disappeared by postoperative day 3.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalEuropean Journal of Ophthalmology
Issue number2
Publication statusPublished - Sep 9 2013



  • Collagen crosslinking
  • Corneal thickness
  • Isotonic riboflavin
  • Pentacam HR

ASJC Scopus subject areas

  • Ophthalmology

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