Intraocular pressure decrease with preservative-free fixed and unfixed combination of tafluprost and timolol in pseudoexfoliative glaucoma

Gábor Holló, Auli Ropo

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We investigated the intraocular pressure (IOP) lowering efficacy of preservative-free fixed and non-fixed combination of tafluprost 0.0015% and timolol 0.5% in pseudoexfoliative glaucoma (XFG). A per protocol worse eye analysis was made on all XFG patients who participated in a recent 6 month, prospective, randomized, double-masked, parallel group, multicenter phase III study. The mean time-wise IOP decreased by 8.62 to 10.25 mmHg (31.8 to 36.7%) in the fixed dose combination arm (15 patients) and by 5.38 to 11.35 mmHg (21.3 to 41.2%) in the non-fixed combination arm (13 patients), respectively (p < 0.001 for all comparisons). The results show that a preservative-free fixed dose combination of tafluprost and timolol provides a clinically significant IOP reduction in XFG, and may offer an advantage for the XFG patients with dry eye, due to its preservative-free nature.

Original languageEnglish
Article number972500
Pages (from-to)13-16
Number of pages4
JournalCurrent Medical Research and Opinion
Issue number1
Publication statusPublished - Jan 1 2015



  • Intraocular pressure
  • Preservative free topical medication
  • Pseudoexfoliative glaucoma
  • Tafluprost/timolol fixed combination

ASJC Scopus subject areas

  • Medicine(all)

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