Intranasal PUVA phototherapy in nasal polyposis--a pilot study.

A. Koreck, Zsolt Bella, Edit Kadocsa, Adam Perenyi, L. Tiszlavicz, Istvan Nemeth, M. Kiss, Tudor Rares Olariu, J. Jóri, L. Kemény

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Nasal polyposis (NP) affects 4% of the general population, representing a major health problem. In spite of complex (surgical and medical) treatment, the relapse rate is high and it has a negative impact on the quality of life. Recently we found that intranasal photochemotherapy with ultraviolet A light (PUVA) is effective in allergic rhinitis. In the present study PUVA was administered for 6 weeks in 7 patients with NP. Nasal lavages were performed in all patients before and at the end of the treatment; from four patients a biopsy specimen was also collected. Eosinophils significantly decreased in patients with NP and slightly in a patient who had associated aspirin sensitivity. IL-5 and eosinophil cationic protein (ECP) levels showed a decreasing trend in patients with NP and an increasing trend in patients with associated aspirin sensitivity. Our results suggest that intranasal PUVA might represent a future therapeutic method in a subset of patients with NP.

Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalRoumanian Archives of Microbiology and Immunology
Volume69
Issue number1
Publication statusPublished - Jan 2010

Fingerprint

Phototherapy
Photochemotherapy
Ultraviolet Rays
Nose
Aspirin
Nasal Lavage
Eosinophil Cationic Protein
Interleukin-5
Eosinophils
Therapeutics
Quality of Life
Biopsy
Recurrence
Health

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)

Cite this

Intranasal PUVA phototherapy in nasal polyposis--a pilot study. / Koreck, A.; Bella, Zsolt; Kadocsa, Edit; Perenyi, Adam; Tiszlavicz, L.; Nemeth, Istvan; Kiss, M.; Olariu, Tudor Rares; Jóri, J.; Kemény, L.

In: Roumanian Archives of Microbiology and Immunology, Vol. 69, No. 1, 01.2010, p. 20-23.

Research output: Contribution to journalArticle

Koreck, A. ; Bella, Zsolt ; Kadocsa, Edit ; Perenyi, Adam ; Tiszlavicz, L. ; Nemeth, Istvan ; Kiss, M. ; Olariu, Tudor Rares ; Jóri, J. ; Kemény, L. / Intranasal PUVA phototherapy in nasal polyposis--a pilot study. In: Roumanian Archives of Microbiology and Immunology. 2010 ; Vol. 69, No. 1. pp. 20-23.
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