Intramolecular mannich reaction of 2-oxotryptamines with acetone yielding spiro[indole-3,3′-pyrrolidin]-2-ones

Mária Incze, Gábor Dörnyei, Mária Kajtár-Peredy, Csaba Szántay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

2-Oxotryptamines undergo intramolecular Mannich-type cyclization with acetone to give 2′,2′-dimethylspiro[indole-3,3′-pyrrolidin]-2-ones. In presence of an alkylating reagent, this reaction gives the corresponding 1′-substituted products.

Original languageEnglish
Pages (from-to)408-416
Number of pages9
JournalCollection of Czechoslovak Chemical Communications
Volume64
Issue number2
DOIs
Publication statusPublished - Jan 1 1999

    Fingerprint

Keywords

  • Alkaloids
  • Cyclizations
  • Indoles
  • Intramolecular mannich reaction
  • Pyrrolidines
  • Spirocyclic compounds

ASJC Scopus subject areas

  • Chemistry(all)

Cite this