Intramolecular mannich reaction of 2-oxotryptamines with acetone yielding spiro[indole-3,3′-pyrrolidin]-2-ones

Mária Incze, Gábor Dörnyei, M. Kajtár-Peredy, Csaba Szántay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

2-Oxotryptamines undergo intramolecular Mannich-type cyclization with acetone to give 2′,2′-dimethylspiro[indole-3,3′-pyrrolidin]-2-ones. In presence of an alkylating reagent, this reaction gives the corresponding 1′-substituted products.

Original languageEnglish
Pages (from-to)408-416
Number of pages9
JournalCollection of Czechoslovak Chemical Communications
Volume64
Issue number2
Publication statusPublished - 1999

Fingerprint

Cyclization
Acetone
indole

Keywords

  • Alkaloids
  • Cyclizations
  • Indoles
  • Intramolecular mannich reaction
  • Pyrrolidines
  • Spirocyclic compounds

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Intramolecular mannich reaction of 2-oxotryptamines with acetone yielding spiro[indole-3,3′-pyrrolidin]-2-ones. / Incze, Mária; Dörnyei, Gábor; Kajtár-Peredy, M.; Szántay, Csaba.

In: Collection of Czechoslovak Chemical Communications, Vol. 64, No. 2, 1999, p. 408-416.

Research output: Contribution to journalArticle

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AU - Szántay, Csaba

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