Intraendothelial accumulation of calcium in the hippocampus and thalamus of rats after systemic kainic acid administration

L. Sztriha, F. Joo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The accumulation of calcium in the hippocampal and thalamic vascular endothelium and the perivascular space was detected histochemically by means of the pyroantimonate technique 30, 60 and 120 min after systemic kainic acid administration. An increased number of calcium pyroantimonate deposits was found in the endothelial mitochondria 60 min after kainate injection. The mitochondria were swollen at this time and vacuoles containing deposits were observed. After 120 min a pronounced perivascular glial swelling was conspicuous, besides the numerouos endothelial mitochondrial deposits. The swollen glial processes contained a large number of pyroantimonate deposits. It seems likely that the transendothelial calcium transport processes are accompanied by intraendothelial calcium accumulation and mitochondrial calcium sequestration.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalActa Neuropathologica
Volume72
Issue number2
DOIs
Publication statusPublished - Jun 1986

Fingerprint

Kainic Acid
Thalamus
Hippocampus
Calcium
Neuroglia
Mitochondria
Vascular Endothelium
Vacuoles
Injections
pyroantimonate

Keywords

  • Calcium uptake
  • Endothelial calcium accumulation
  • Hippocampus
  • Kamic acid seizures
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Intraendothelial accumulation of calcium in the hippocampus and thalamus of rats after systemic kainic acid administration. / Sztriha, L.; Joo, F.

In: Acta Neuropathologica, Vol. 72, No. 2, 06.1986, p. 111-116.

Research output: Contribution to journalArticle

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