Intracranial volume inversely correlates with serum 25(OH)d level in healthy young women

Enikő Plózer, Anna Altbäcker, Gergely Darnai, Gábor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Attila Schwarcz, Tamás Koszegi, Gábor László Woth, Tivadar Lucza, Norbert Kovács, Sámuel Komoly, Zsófia Clemens, József Janszky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: Vitamin D is important in normal brain development. In animals low vitamin D level is associated with brain morphological alterations including enlargement of the brain. Whether a similar association exists

in humans is unknown. Here we investigated the relationship between vitamin D and total intracranial volume as well as total volume of the cortical grey and cerebral white matter and that of the ventricles in young healthy women.

Methods: To assess volumes we applied semi-automatic user-independent MR volumetry. For the vitamin D measurements automated electrochemiluminescence immunoassay was used.

Results: We found a significant negative correlation between vitamin D and total intracranial volume as well as total cortical grey and cerebral white matter volumes.

Discussion: This association may reflect a trait-like relationship between vitamin D and brain size possibly determined in early development.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalNutritional Neuroscience
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • 25(OH)D
  • Brain volumetry
  • Intracranial volume
  • MRI
  • Vitamin D

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Intracranial volume inversely correlates with serum 25(OH)d level in healthy young women'. Together they form a unique fingerprint.

  • Cite this