Intracranial neuronal ensemble recordings and analysis in epilepsy

Emília Tóth, Dániel Fabó, László Entz, István Ulbert, Loránd Eross

Research output: Contribution to journalReview article

7 Citations (Scopus)


Pathological neuronal firing was demonstrated 50 years ago as the hallmark of epileptically transformed cortex with the use of implanted microelectrodes. Since then, microelectrodes remained only experimental tools in humans to detect unitary neuronal activity to reveal physiological and pathological brain functions. This recording technique has evolved substantially in the past few decades; however, based on recent human data implying their usefulness as diagnostic tools, we expect a substantial increase in the development of microelectrodes in the near future. Here, we review the technological background and history of microelectrode array development for human examinations in epilepsy, including discussions on of wire-based and microelectrode arrays fabricated using micro-electro-mechanical system (MEMS) techniques and novel future techniques to record neuronal ensemble. We give an overview of clinical and surgical considerations, and try to provide a list of probes on the market with their availability for human recording.Then finally, we briefly review the literature on modulation of single neuron for the treatment of epilepsy, and highlight the current topics under examination that can be background for the future development.

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalJournal of Neuroscience Methods
Publication statusPublished - Feb 15 2016



  • Epilepsy
  • Human
  • Intracranial
  • Micro-electrode
  • Multi-electrode array
  • Single unit recording

ASJC Scopus subject areas

  • Neuroscience(all)

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