Intracoronary endothelin-1 infusion combined with systemic isoproterenol treatment

Antagonistic arrhythmogenic effects

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Endothelin-1 secretion and sympathetic activation may play important role in cardiovascular pathophysiology. In vivo interactions between these systems are not defined. We aimed to study the electrophysiological and haemodynamic effects of simultaneous intracoronary endothelin-1 and intravenous isoproterenol infusions. 18 anaesthetised open chest dogs were studied after AV-ablation. Mean arterial blood pressure, coronary blood flow, left ventricular contractility, standard electrocardiograms, right and left ventricular epi- and endocardial monophasic action potential (MAP) signals were recorded. Intracoronary endothelin-1 (30 pmol/min) was given to Group ET (n=6), intravenous isoproterenol (0.2 μg/kg/min) to Group ISO (n=6), both endothelin-1 and isoproterenol to Group ET+ISO (n=6) for 30 min. MAP duration increased in all studied regions of Group ET, decreased in all studied regions of Group ISO and ET+ISO (control vs. maximal changes of left ventricular epicardial MAP 90% duration, Group ET: 296±22 vs 369±20 ms, p

Original languageEnglish
Pages (from-to)537-548
Number of pages12
JournalLife Sciences
Volume75
Issue number5
DOIs
Publication statusPublished - Jun 18 2004

Fingerprint

Endothelin-1
Isoproterenol
Action Potentials
Arterial Pressure
Blood pressure
Hemodynamics
Therapeutics
Ablation
Electrocardiography
Intravenous Infusions
Blood
Thorax
Chemical activation
Dogs

Keywords

  • Adrenergic agonists
  • Arrhythmia (mechanisms)
  • Endothelins

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "Endothelin-1 secretion and sympathetic activation may play important role in cardiovascular pathophysiology. In vivo interactions between these systems are not defined. We aimed to study the electrophysiological and haemodynamic effects of simultaneous intracoronary endothelin-1 and intravenous isoproterenol infusions. 18 anaesthetised open chest dogs were studied after AV-ablation. Mean arterial blood pressure, coronary blood flow, left ventricular contractility, standard electrocardiograms, right and left ventricular epi- and endocardial monophasic action potential (MAP) signals were recorded. Intracoronary endothelin-1 (30 pmol/min) was given to Group ET (n=6), intravenous isoproterenol (0.2 μg/kg/min) to Group ISO (n=6), both endothelin-1 and isoproterenol to Group ET+ISO (n=6) for 30 min. MAP duration increased in all studied regions of Group ET, decreased in all studied regions of Group ISO and ET+ISO (control vs. maximal changes of left ventricular epicardial MAP 90{\%} duration, Group ET: 296±22 vs 369±20 ms, p",
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