Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats

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Abstract

In the present study the effect of intracerebroventricularly (ICV) administered somatostatin on electroconvulsive shock- (ECS) induced retrograde amnesia was investigated in rats. The ECS significantly decreased foot shock-induced avoidance latency. Somatostatin in a dose of 1 μg 4 μl (ICV) had no action on the ECS-induced retrograde amnesia, while in a dose of 4 μg 4 μl it significantly increased the avoidance latency if the treatment was performed immediately, 4 hr, 20 hr or 23 hr after the ECS. The results suggest that ICV administered somatostatin has an antiamnesic effect.

Original languageEnglish
Pages (from-to)293-295
Number of pages3
JournalPeptides
Volume4
Issue number3
DOIs
Publication statusPublished - Jan 1 1983

Keywords

  • Amnesia
  • Electroconvulsive shock
  • Passive avoidance
  • Rats
  • Somatostatin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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