Intracellular trafficking of hormone receptors

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Agonist binding stimulates endocytosis of hormone receptors via vesicular uptake mechanisms. Interactions of the intracellular domains of receptors with specific targeting proteins are crucial for sorting of internalized receptor in endosomes. Some receptors are targeted for very rapid (e.g. β2-adrenergic receptor) or slower (e.g. AT 1 angiotensin receptor) recycling pathways, whereas others are targeted to lysosomes for degradation (e.g. EGF receptor or PAR1 protease-activated receptor). This review discusses the mechanisms involved in these processes, which regulate surface receptor expression and set the stage for intracellular signaling of G protein-coupled and growth factor receptors.

Original languageEnglish
Pages (from-to)286-293
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume15
Issue number6
DOIs
Publication statusPublished - Aug 2004

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Intracellular Signaling Peptides and Proteins
Proteinase-Activated Receptors
Angiotensin Receptors
Growth Factor Receptors
Endosomes
Protein Transport
Endocytosis
Lysosomes
GTP-Binding Proteins
Epidermal Growth Factor Receptor
Adrenergic Receptors
Hormones

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Intracellular trafficking of hormone receptors. / Gáborik, Z.; Hunyady, L.

In: Trends in Endocrinology and Metabolism, Vol. 15, No. 6, 08.2004, p. 286-293.

Research output: Contribution to journalArticle

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