Low density lipoprotein receptorok intracelluláris jeltovábbítása humán monocytákban.

Translated title of the contribution: Intracellular signal transmission of low density lipoprotein receptors in human monocytes

Z. Balogh, E. Kovács, G. Paragh, M. Szabolcs, T. Keresztes, A. Leövey, G. Fóris

Research output: Contribution to journalReview article

Abstract

The authors found that in human monocytes administered low density lipoprotein in doses of 50 micrograms had optimal inhibition of endogenous cholesterol synthesis which measured by [14C] acetate incorporation. There was not effect of pertussis toxin and phorbol myristate acetate on the inhibiton of endogenous cholesterol synthesis, whereas calcium channel blocker verapamil and phospholipase A2-inhibitor chloroquine decreased it. In contrast, the protein kinase C-stimulant phorbol myristate acetate alone had effects as LDL, but the protein kinase C-inhibitor H-7 had antagonist effect against LDL. Inositol phosphate generation was induced by administration of LDL in doses of 50 micrograms, which was pertussis toxin insensitive. The calcium signal was not also pertussis toxin sensitive, while occurred an intensive protein kinase C activation by administration of LDL. In signal transduction of monocytes activated by LDL may be an important role of the opening of calcium channels and activation of two enzymes, such as phospholipase A2 and protein kinase C.

Translated title of the contributionIntracellular signal transmission of low density lipoprotein receptors in human monocytes
Original languageHungarian
Pages (from-to)2318-2321
Number of pages4
JournalOrvosi hetilap
Volume138
Issue number36 Suppl 2
Publication statusPublished - Sep 7 1997

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Balogh, Z., Kovács, E., Paragh, G., Szabolcs, M., Keresztes, T., Leövey, A., & Fóris, G. (1997). Low density lipoprotein receptorok intracelluláris jeltovábbítása humán monocytákban. Orvosi hetilap, 138(36 Suppl 2), 2318-2321.