Intracellular 'labyrinths' in acute leukaemia. Do they indicate the maturational ability of leukaemic cells?

G. Lelkes, Gy Lelkes, K. Natonek, S. Hollán

Research output: Contribution to journalArticle

Abstract

The occurrence and ultrastructure of the so-called 'labyrinths' were investigated in the bone marrow cells from 13 patients with preleukaemia and acute leukaemia. Except for one patient, labyrinths were found in the myeloid cells from patients with preleukaemia and acute myelogenous leukaemia. Labyrinths could not be detected in lymphoblasts from patients suffering from acute lymphoblastic leukaemia or in plasma cells from a patient with plasma cell leukaemia. In patients with preleukaemia and smoldering leukaemia, labyrinths could be detected in all differentiation forms, from myeloblasts to mature polymorphonuclear granulocytes. Since it is improbable that labyrinths develop in consequence of exogenous effects, their presence in the mature granulocyes points to the in vivo maturational ability of leukaemic precursors in certain cases of acute myelogenous leukaemia and preleukaemia.

Original languageEnglish
Pages (from-to)293-306
Number of pages14
JournalHaematologia
Volume14
Issue number3
Publication statusPublished - 1981

Fingerprint

Inner Ear
Preleukemia
Leukemia
Acute Myeloid Leukemia
Plasma Cell Leukemia
Refractory Anemia with Excess of Blasts
Granulocyte Precursor Cells
Myeloid Cells
Plasma Cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Granulocytes
Bone Marrow Cells

ASJC Scopus subject areas

  • Hematology

Cite this

Intracellular 'labyrinths' in acute leukaemia. Do they indicate the maturational ability of leukaemic cells? / Lelkes, G.; Lelkes, Gy; Natonek, K.; Hollán, S.

In: Haematologia, Vol. 14, No. 3, 1981, p. 293-306.

Research output: Contribution to journalArticle

@article{fc9c6dbc4729489f8c1fedb8cd1e56a0,
title = "Intracellular 'labyrinths' in acute leukaemia. Do they indicate the maturational ability of leukaemic cells?",
abstract = "The occurrence and ultrastructure of the so-called 'labyrinths' were investigated in the bone marrow cells from 13 patients with preleukaemia and acute leukaemia. Except for one patient, labyrinths were found in the myeloid cells from patients with preleukaemia and acute myelogenous leukaemia. Labyrinths could not be detected in lymphoblasts from patients suffering from acute lymphoblastic leukaemia or in plasma cells from a patient with plasma cell leukaemia. In patients with preleukaemia and smoldering leukaemia, labyrinths could be detected in all differentiation forms, from myeloblasts to mature polymorphonuclear granulocytes. Since it is improbable that labyrinths develop in consequence of exogenous effects, their presence in the mature granulocyes points to the in vivo maturational ability of leukaemic precursors in certain cases of acute myelogenous leukaemia and preleukaemia.",
author = "G. Lelkes and Gy Lelkes and K. Natonek and S. Holl{\'a}n",
year = "1981",
language = "English",
volume = "14",
pages = "293--306",
journal = "Haematologia",
issn = "0017-6559",
publisher = "VSP BV",
number = "3",

}

TY - JOUR

T1 - Intracellular 'labyrinths' in acute leukaemia. Do they indicate the maturational ability of leukaemic cells?

AU - Lelkes, G.

AU - Lelkes, Gy

AU - Natonek, K.

AU - Hollán, S.

PY - 1981

Y1 - 1981

N2 - The occurrence and ultrastructure of the so-called 'labyrinths' were investigated in the bone marrow cells from 13 patients with preleukaemia and acute leukaemia. Except for one patient, labyrinths were found in the myeloid cells from patients with preleukaemia and acute myelogenous leukaemia. Labyrinths could not be detected in lymphoblasts from patients suffering from acute lymphoblastic leukaemia or in plasma cells from a patient with plasma cell leukaemia. In patients with preleukaemia and smoldering leukaemia, labyrinths could be detected in all differentiation forms, from myeloblasts to mature polymorphonuclear granulocytes. Since it is improbable that labyrinths develop in consequence of exogenous effects, their presence in the mature granulocyes points to the in vivo maturational ability of leukaemic precursors in certain cases of acute myelogenous leukaemia and preleukaemia.

AB - The occurrence and ultrastructure of the so-called 'labyrinths' were investigated in the bone marrow cells from 13 patients with preleukaemia and acute leukaemia. Except for one patient, labyrinths were found in the myeloid cells from patients with preleukaemia and acute myelogenous leukaemia. Labyrinths could not be detected in lymphoblasts from patients suffering from acute lymphoblastic leukaemia or in plasma cells from a patient with plasma cell leukaemia. In patients with preleukaemia and smoldering leukaemia, labyrinths could be detected in all differentiation forms, from myeloblasts to mature polymorphonuclear granulocytes. Since it is improbable that labyrinths develop in consequence of exogenous effects, their presence in the mature granulocyes points to the in vivo maturational ability of leukaemic precursors in certain cases of acute myelogenous leukaemia and preleukaemia.

UR - http://www.scopus.com/inward/record.url?scp=0019809994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019809994&partnerID=8YFLogxK

M3 - Article

C2 - 6276273

AN - SCOPUS:0019809994

VL - 14

SP - 293

EP - 306

JO - Haematologia

JF - Haematologia

SN - 0017-6559

IS - 3

ER -