Intracellular free calcium concentration in lymphocytes of patients with muscular dystrophies

Ferenc Mechler, Mária Molnár, M. Balázs, J. Matkó

Research output: Contribution to journalArticle

Abstract

Intracellular free calcium concentration ([Ca2+]i) of human peripheral blood lymphocytes was determined by fluorescence spectroscopic measurements with quin2 in patients with different types of muscular dystrophy and in controls. The [Ca2+]i level in lymphocytes showed a significant increase in adult type (faciocapulohumeral and limb-girdle) muscular dystrophies, while it showed a decrease in Duchenne dystrophy as compared to the values of age- and sex-matched controls. The data obtained suggest an alteration in the effectiveness of the calcium pump in lymphocytes and may represent a sign of generalized membrane damage in these hereditary muscle diseases.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1012
Issue number3
DOIs
Publication statusPublished - Aug 15 1989

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Muscular Dystrophies
Lymphocytes
Calcium
Limb-Girdle Muscular Dystrophies
Inborn Genetic Diseases
Fluorescence
Muscles
Membranes

Keywords

  • (Human lymphocyte)
  • Calcium ion
  • intracellular
  • Lymphocyte
  • Muscular dystrophy

ASJC Scopus subject areas

  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Intracellular free calcium concentration in lymphocytes of patients with muscular dystrophies. / Mechler, Ferenc; Molnár, Mária; Balázs, M.; Matkó, J.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1012, No. 3, 15.08.1989, p. 227-230.

Research output: Contribution to journalArticle

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