Intracardiac calcification is a marker of generalized atherosclerosis

János Nemcsik, Katalin Farkas, Endre Kolossváry, Z. Járai, József Egresits, Gábor Borgulya, István Kiss, M. Lengyel

Research output: Contribution to journalArticle

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Abstract

Aortic valve calcification (AVC) and carotid artery calcification (CAC) are considered to be markers of generalized atherosclerosis. However, the role of intracardiac calcification (ICC) (valvular and perivalvular calcification) is unclear. The objective of this retrospective study was to analyze the relationship between ICC and CAC, risk factors, and clinical atherosclerotic disease. Risk factors included age, sex, diabetes mellitus, hypercholesterolemia, and hypertension; clinical atherosclerosis comprised stroke, coronary artery disease, and peripheral artery disease. Between January 1, 2001, and January 1, 2004, all consecutive patients were enrolled into the study who underwent both carotid ultrasonography and transthoracic echocardiography examinations within 2 months. Patients with renal failure, substantial aortic stenosis, and carotid artery occlusion were excluded. There were 320 patients (104 men; mean ± SEM age, 66.6 ± 0.76 years). Positive results on carotid ultrasonography are defined as any CAC. Patients were categorized as having mild, moderate, or severe CAC. Positive results on transthoracic echocardiography were defined as any ICC; AVC was defined as mitral anulus calcification (MAC) or both. Intracardiac calcification was found in 181 patients, AVC in 51 patients, MAC in 48 patients, and calcification of both structures in 82 patients. Using multiple logistic regression analysis, ICC (odds ratio, 1.9), age (10-year periods) (odds ratio, 2.0), and the presence of peripheral artery disease (odds ratio, 1.7) were independent predictors of CAC. Carotid ultrasonography results were positive in 227 patients. For CAC, the sensitivities of AVC, MAC, both, and any ICC were 52.4%, 52.0%, 33.5%, and 71.2%, respectively, and the specificities were 84.9%, 87.1%, 92.5%, and 78.5%, respectively. The extension of ICC as 0, 1 location (AVC or MAC) , or 2 locations (AVC and MAC) was associated with the severity of CAC (P

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalAngiology
Volume58
Issue number4
DOIs
Publication statusPublished - Aug 2007

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Carotid Arteries
Atherosclerosis
Ultrasonography
Peripheral Arterial Disease
Odds Ratio
Echocardiography
Aortic Valve Stenosis
Hypercholesterolemia
Renal Insufficiency
Calcification of Aortic Valve
Coronary Artery Disease
Diabetes Mellitus
Retrospective Studies
Logistic Models
Stroke
Regression Analysis
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Intracardiac calcification is a marker of generalized atherosclerosis. / Nemcsik, János; Farkas, Katalin; Kolossváry, Endre; Járai, Z.; Egresits, József; Borgulya, Gábor; Kiss, István; Lengyel, M.

In: Angiology, Vol. 58, No. 4, 08.2007, p. 413-419.

Research output: Contribution to journalArticle

Nemcsik, J, Farkas, K, Kolossváry, E, Járai, Z, Egresits, J, Borgulya, G, Kiss, I & Lengyel, M 2007, 'Intracardiac calcification is a marker of generalized atherosclerosis', Angiology, vol. 58, no. 4, pp. 413-419. https://doi.org/10.1177/0003319706291112
Nemcsik J, Farkas K, Kolossváry E, Járai Z, Egresits J, Borgulya G et al. Intracardiac calcification is a marker of generalized atherosclerosis. Angiology. 2007 Aug;58(4):413-419. https://doi.org/10.1177/0003319706291112
Nemcsik, János ; Farkas, Katalin ; Kolossváry, Endre ; Járai, Z. ; Egresits, József ; Borgulya, Gábor ; Kiss, István ; Lengyel, M. / Intracardiac calcification is a marker of generalized atherosclerosis. In: Angiology. 2007 ; Vol. 58, No. 4. pp. 413-419.
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