Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life

Diane M. Gray, Dorottya Czovek, Lauren McMillan, Lidija Turkovic, Jacob A.M. Stadler, Anessa Vanker, Bence L. Radics, Z. Gingl, Graham L. Hall, Peter D. Sly, Heather J. Zar, Z. Hantos

Research output: Contribution to journalArticle

Abstract

Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and noninvasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. The objective of this study was to investigate whether lung function derived from the intra-breath forced oscillation technique (FOT) was able to identify healthy infants at risk of LRTI in the first year of life. Lung function was measured with the novel intra-breath FOT, in 6-week-old infants in a South African birth cohort (Drakenstein Child Health Study). LRTI during the first year was confirmed by study staff. The association between baseline lung function and LRTI was assessed with logistic regression and odds ratios determined using optimal cut-off values. Of the 627 healthy infants with successful lung function testing, 161 (24%) had 238 LRTI episodes subsequently during the first year. Volume dependence of respiratory resistance (ΔR) and reactance (ΔX) was associated with LRTI. The predictive value was stronger if LRTI was recurrent (n=50 (31%): OR 2.5, ΔX), required hospitalisation (n=38 (16%): OR 5.4, ΔR) or was associated with wheeze (n=87 (37%): OR 3.9, ΔX). Intra-breath FOT can identify healthy infants at risk of developing LRTI, wheezing or severe illness in the first year of life.

Original languageEnglish
Article number1800998
JournalEuropean Respiratory Journal
Volume53
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

Fingerprint

Respiratory Mechanics
Respiratory System
Lung
Respiratory Sounds
Hospitalization
Logistic Models
Odds Ratio
Parturition
Morbidity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life. / Gray, Diane M.; Czovek, Dorottya; McMillan, Lauren; Turkovic, Lidija; Stadler, Jacob A.M.; Vanker, Anessa; Radics, Bence L.; Gingl, Z.; Hall, Graham L.; Sly, Peter D.; Zar, Heather J.; Hantos, Z.

In: European Respiratory Journal, Vol. 53, No. 2, 1800998, 01.02.2019.

Research output: Contribution to journalArticle

Gray, DM, Czovek, D, McMillan, L, Turkovic, L, Stadler, JAM, Vanker, A, Radics, BL, Gingl, Z, Hall, GL, Sly, PD, Zar, HJ & Hantos, Z 2019, 'Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life', European Respiratory Journal, vol. 53, no. 2, 1800998. https://doi.org/10.1183/13993003.00998-2018
Gray, Diane M. ; Czovek, Dorottya ; McMillan, Lauren ; Turkovic, Lidija ; Stadler, Jacob A.M. ; Vanker, Anessa ; Radics, Bence L. ; Gingl, Z. ; Hall, Graham L. ; Sly, Peter D. ; Zar, Heather J. ; Hantos, Z. / Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life. In: European Respiratory Journal. 2019 ; Vol. 53, No. 2.
@article{c06bb832e8f74628b59ca878ccfa845e,
title = "Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life",
abstract = "Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and noninvasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. The objective of this study was to investigate whether lung function derived from the intra-breath forced oscillation technique (FOT) was able to identify healthy infants at risk of LRTI in the first year of life. Lung function was measured with the novel intra-breath FOT, in 6-week-old infants in a South African birth cohort (Drakenstein Child Health Study). LRTI during the first year was confirmed by study staff. The association between baseline lung function and LRTI was assessed with logistic regression and odds ratios determined using optimal cut-off values. Of the 627 healthy infants with successful lung function testing, 161 (24{\%}) had 238 LRTI episodes subsequently during the first year. Volume dependence of respiratory resistance (ΔR) and reactance (ΔX) was associated with LRTI. The predictive value was stronger if LRTI was recurrent (n=50 (31{\%}): OR 2.5, ΔX), required hospitalisation (n=38 (16{\%}): OR 5.4, ΔR) or was associated with wheeze (n=87 (37{\%}): OR 3.9, ΔX). Intra-breath FOT can identify healthy infants at risk of developing LRTI, wheezing or severe illness in the first year of life.",
author = "Gray, {Diane M.} and Dorottya Czovek and Lauren McMillan and Lidija Turkovic and Stadler, {Jacob A.M.} and Anessa Vanker and Radics, {Bence L.} and Z. Gingl and Hall, {Graham L.} and Sly, {Peter D.} and Zar, {Heather J.} and Z. Hantos",
year = "2019",
month = "2",
day = "1",
doi = "10.1183/13993003.00998-2018",
language = "English",
volume = "53",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "2",

}

TY - JOUR

T1 - Intra-breath measures of respiratory mechanics in healthy African infants detect risk of respiratory illness in early life

AU - Gray, Diane M.

AU - Czovek, Dorottya

AU - McMillan, Lauren

AU - Turkovic, Lidija

AU - Stadler, Jacob A.M.

AU - Vanker, Anessa

AU - Radics, Bence L.

AU - Gingl, Z.

AU - Hall, Graham L.

AU - Sly, Peter D.

AU - Zar, Heather J.

AU - Hantos, Z.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and noninvasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. The objective of this study was to investigate whether lung function derived from the intra-breath forced oscillation technique (FOT) was able to identify healthy infants at risk of LRTI in the first year of life. Lung function was measured with the novel intra-breath FOT, in 6-week-old infants in a South African birth cohort (Drakenstein Child Health Study). LRTI during the first year was confirmed by study staff. The association between baseline lung function and LRTI was assessed with logistic regression and odds ratios determined using optimal cut-off values. Of the 627 healthy infants with successful lung function testing, 161 (24%) had 238 LRTI episodes subsequently during the first year. Volume dependence of respiratory resistance (ΔR) and reactance (ΔX) was associated with LRTI. The predictive value was stronger if LRTI was recurrent (n=50 (31%): OR 2.5, ΔX), required hospitalisation (n=38 (16%): OR 5.4, ΔR) or was associated with wheeze (n=87 (37%): OR 3.9, ΔX). Intra-breath FOT can identify healthy infants at risk of developing LRTI, wheezing or severe illness in the first year of life.

AB - Lower respiratory tract illness (LRTI) is a leading cause of mortality and morbidity in children. Sensitive and noninvasive infant lung function techniques are needed to measure risk for and impact of LRTI on lung health. The objective of this study was to investigate whether lung function derived from the intra-breath forced oscillation technique (FOT) was able to identify healthy infants at risk of LRTI in the first year of life. Lung function was measured with the novel intra-breath FOT, in 6-week-old infants in a South African birth cohort (Drakenstein Child Health Study). LRTI during the first year was confirmed by study staff. The association between baseline lung function and LRTI was assessed with logistic regression and odds ratios determined using optimal cut-off values. Of the 627 healthy infants with successful lung function testing, 161 (24%) had 238 LRTI episodes subsequently during the first year. Volume dependence of respiratory resistance (ΔR) and reactance (ΔX) was associated with LRTI. The predictive value was stronger if LRTI was recurrent (n=50 (31%): OR 2.5, ΔX), required hospitalisation (n=38 (16%): OR 5.4, ΔR) or was associated with wheeze (n=87 (37%): OR 3.9, ΔX). Intra-breath FOT can identify healthy infants at risk of developing LRTI, wheezing or severe illness in the first year of life.

UR - http://www.scopus.com/inward/record.url?scp=85061435907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061435907&partnerID=8YFLogxK

U2 - 10.1183/13993003.00998-2018

DO - 10.1183/13993003.00998-2018

M3 - Article

C2 - 30464010

AN - SCOPUS:85061435907

VL - 53

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 2

M1 - 1800998

ER -