Intima-media thickness of the carotid arteries in subjects with hyperinsulinaemia (insulin resistance)

T. Hidvégi, F. Szatmári, K. Hetyési, L. Bíró, G. Jermendy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The metabolic syndrome is characterised by hyperinsulinaemia (insulin resistance) leading to an increased risk of atherosclerotic cardiovascular diseases. Carotid intima-media thickness (IMT) can be easily measured to detect early atherosclerosis. In order to evaluate the clinical characteristics of the metabolic syndrome a screening procedure was performed and carotid IMT was determined by high-resolution B-mode ultrasonography in a cohort of middle-aged (40-60 years) subjects who proved to be hyperinsulinaemic [fasting plasma insulin >15 μU/ml and/or post-prandial (120 min) insulin >45 μU/ml; n=91; men/women: 35/56; homeostasis model assessment (HOMA)-index: 6.42±3.65; x±SD]. Subjects known to have diabetes were not involved. Subjects were divided into sub-groups according to the stages of glucose intolerance (normal glucose tolerance, n=46; impaired glucose tolerance, n=26; diabetes mellitus, n=19). As controls, age- and sex-matched non-diabetic and non-hyperinsulinaemic subjects (n=20; HOMA-index: 2.09±0.85) were investigated. The values of IMT of the internal carotid arteries were higher in hyperinsulinaemic subjects than in controls (0.93±0.39 mm vs 0.57±0.13 mm, p

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Volume16
Issue number3
Publication statusPublished - Jun 2003

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Carotid Intima-Media Thickness
Glucose Intolerance
hyperinsulinemia
carotid arteries
Hyperinsulinism
Carotid Arteries
insulin resistance
Insulin Resistance
Homeostasis
metabolic syndrome
glucose tolerance
Insulin
homeostasis
Internal Carotid Artery
insulin
middle-aged adults
Meals
Fasting
Ultrasonography
Atherosclerosis

Keywords

  • Diabetes mellitus
  • Hyperinsulinaemia
  • Insulin resistance
  • Intima-media thickness
  • Metabolic syndrome

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Internal Medicine
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Intima-media thickness of the carotid arteries in subjects with hyperinsulinaemia (insulin resistance). / Hidvégi, T.; Szatmári, F.; Hetyési, K.; Bíró, L.; Jermendy, G.

In: Diabetes, Nutrition and Metabolism - Clinical and Experimental, Vol. 16, No. 3, 06.2003, p. 139-144.

Research output: Contribution to journalArticle

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