Interspecific hybridisation between Candida albicans and Candida tropicalis

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Protoplasts from auxotrophic mutants of Candida albicans and Candida tropicalis were produced by snail enzyme treatment and their fusion was induced with polyethylene glycol (PEG). During selective regeneration, nutritionally complemented interspecific hybrids were obtained. Their cells contained one nucleus, and the DNA content per cell was higher than in the parents. The isoenzymic and sugar assimilation patterns of the mutants, and those of the hybrids and the products after their haploidisation, were also analysed. The results indicated that the hybrids were partial alloploids containing the total chromosomal set of either of the parental species and one or a few chromosomes of the other.

Original languageEnglish
Pages (from-to)315-318
Number of pages4
JournalFEMS microbiology letters
Issue number2-3
Publication statusPublished - Sep 1986



  • Candida albicans
  • Candida tropicalis
  • hybridisation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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