Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries

R. Smolders, E. Den Hond, G. Koppen, E. Govarts, H. Willems, L. Casteleyn, M. Kolossa-Gehring, U. Fiddicke, A. Castaño, H. M. Koch, J. Angerer, M. Esteban, O. Sepai, K. Exley, L. Bloemen, M. Horvat, L. E. Knudsen, A. Joas, R. Joas, P. BiotD. Aerts, A. Katsonouri, A. Hadjipanayis, M. Cerna, A. Krskova, G. Schwedler, M. Seiwert, J. K S Nielsen, P. Rudnai, S. Közepesy, D. S. Evans, M. P. Ryan, A. C. Gutleb, M. E. Fischer, D. Ligocka, M. Jakubowski, M. F. Reis, S. Namorado, I. R. Lupsa, A. E. Gurzau, K. Halzlova, E. Fabianova, D. Mazej, J. Tratnik Snoj, S. Gomez, S. González, M. Berglund, K. Larsson, A. Lehmann, P. Crettaz, G. Schoeters

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle.In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.

Original languageEnglish
Pages (from-to)86-95
Number of pages10
JournalEnvironmental Research
Volume141
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Cotinine
Environmental Monitoring
Biomarkers
Mercury
Cadmium
Hair
biomarker
Life Style
biomonitoring
hair
lifestyle
environmental quality
Food Quality
Policy Making
Information Storage and Retrieval
cadmium
Metabolites
Legislation
Fish
Fishes

Keywords

  • COPHES
  • DEMOCOPHES
  • External exposure data
  • Human biomonitoring
  • Interpretation

ASJC Scopus subject areas

  • Environmental Science(all)
  • Biochemistry
  • Medicine(all)

Cite this

Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects : Using external exposure data to understand biomarker differences among countries. / Smolders, R.; Den Hond, E.; Koppen, G.; Govarts, E.; Willems, H.; Casteleyn, L.; Kolossa-Gehring, M.; Fiddicke, U.; Castaño, A.; Koch, H. M.; Angerer, J.; Esteban, M.; Sepai, O.; Exley, K.; Bloemen, L.; Horvat, M.; Knudsen, L. E.; Joas, A.; Joas, R.; Biot, P.; Aerts, D.; Katsonouri, A.; Hadjipanayis, A.; Cerna, M.; Krskova, A.; Schwedler, G.; Seiwert, M.; Nielsen, J. K S; Rudnai, P.; Közepesy, S.; Evans, D. S.; Ryan, M. P.; Gutleb, A. C.; Fischer, M. E.; Ligocka, D.; Jakubowski, M.; Reis, M. F.; Namorado, S.; Lupsa, I. R.; Gurzau, A. E.; Halzlova, K.; Fabianova, E.; Mazej, D.; Tratnik Snoj, J.; Gomez, S.; González, S.; Berglund, M.; Larsson, K.; Lehmann, A.; Crettaz, P.; Schoeters, G.

In: Environmental Research, Vol. 141, 01.08.2015, p. 86-95.

Research output: Contribution to journalArticle

Smolders, R, Den Hond, E, Koppen, G, Govarts, E, Willems, H, Casteleyn, L, Kolossa-Gehring, M, Fiddicke, U, Castaño, A, Koch, HM, Angerer, J, Esteban, M, Sepai, O, Exley, K, Bloemen, L, Horvat, M, Knudsen, LE, Joas, A, Joas, R, Biot, P, Aerts, D, Katsonouri, A, Hadjipanayis, A, Cerna, M, Krskova, A, Schwedler, G, Seiwert, M, Nielsen, JKS, Rudnai, P, Közepesy, S, Evans, DS, Ryan, MP, Gutleb, AC, Fischer, ME, Ligocka, D, Jakubowski, M, Reis, MF, Namorado, S, Lupsa, IR, Gurzau, AE, Halzlova, K, Fabianova, E, Mazej, D, Tratnik Snoj, J, Gomez, S, González, S, Berglund, M, Larsson, K, Lehmann, A, Crettaz, P & Schoeters, G 2015, 'Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries', Environmental Research, vol. 141, pp. 86-95. https://doi.org/10.1016/j.envres.2014.08.016
Smolders, R. ; Den Hond, E. ; Koppen, G. ; Govarts, E. ; Willems, H. ; Casteleyn, L. ; Kolossa-Gehring, M. ; Fiddicke, U. ; Castaño, A. ; Koch, H. M. ; Angerer, J. ; Esteban, M. ; Sepai, O. ; Exley, K. ; Bloemen, L. ; Horvat, M. ; Knudsen, L. E. ; Joas, A. ; Joas, R. ; Biot, P. ; Aerts, D. ; Katsonouri, A. ; Hadjipanayis, A. ; Cerna, M. ; Krskova, A. ; Schwedler, G. ; Seiwert, M. ; Nielsen, J. K S ; Rudnai, P. ; Közepesy, S. ; Evans, D. S. ; Ryan, M. P. ; Gutleb, A. C. ; Fischer, M. E. ; Ligocka, D. ; Jakubowski, M. ; Reis, M. F. ; Namorado, S. ; Lupsa, I. R. ; Gurzau, A. E. ; Halzlova, K. ; Fabianova, E. ; Mazej, D. ; Tratnik Snoj, J. ; Gomez, S. ; González, S. ; Berglund, M. ; Larsson, K. ; Lehmann, A. ; Crettaz, P. ; Schoeters, G. / Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects : Using external exposure data to understand biomarker differences among countries. In: Environmental Research. 2015 ; Vol. 141. pp. 86-95.
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AU - Smolders, R.

AU - Den Hond, E.

AU - Koppen, G.

AU - Govarts, E.

AU - Willems, H.

AU - Casteleyn, L.

AU - Kolossa-Gehring, M.

AU - Fiddicke, U.

AU - Castaño, A.

AU - Koch, H. M.

AU - Angerer, J.

AU - Esteban, M.

AU - Sepai, O.

AU - Exley, K.

AU - Bloemen, L.

AU - Horvat, M.

AU - Knudsen, L. E.

AU - Joas, A.

AU - Joas, R.

AU - Biot, P.

AU - Aerts, D.

AU - Katsonouri, A.

AU - Hadjipanayis, A.

AU - Cerna, M.

AU - Krskova, A.

AU - Schwedler, G.

AU - Seiwert, M.

AU - Nielsen, J. K S

AU - Rudnai, P.

AU - Közepesy, S.

AU - Evans, D. S.

AU - Ryan, M. P.

AU - Gutleb, A. C.

AU - Fischer, M. E.

AU - Ligocka, D.

AU - Jakubowski, M.

AU - Reis, M. F.

AU - Namorado, S.

AU - Lupsa, I. R.

AU - Gurzau, A. E.

AU - Halzlova, K.

AU - Fabianova, E.

AU - Mazej, D.

AU - Tratnik Snoj, J.

AU - Gomez, S.

AU - González, S.

AU - Berglund, M.

AU - Larsson, K.

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AU - Crettaz, P.

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