Interplay of immunoglobulin G heavy chain markers (Gm) and HLA in predisposing to systemic lupus nephritis

V. Stenszky, L. Kozma, G. Szegedi, N. R. Farid

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We have studied the distribution of IgG heavy chain markers (Gm) among 90 Hungarian patients with systemic lupus erythematosus (SLE) (55 of whom were also typed for HLA). This study confirms previously described increases in HLA-B8 and DR3 in this condition. No difference in the distribution of Gm phenotypes was found between patients and 168 controls from the same geographical area. HLA-B8/Gm homozygous individuals were, however, at greater risk for SLE (relative risk = 5·13) compared to B8 + Gm heterozygotes or B8- individuals, irrespective of Gm phenotype. When patients with renal manifestation (n=40) were compared to those without, the Gm phenotype 3; 5, 13 was found to be significantly increased (χ2=10·36, P

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalJournal of Immunogenetics
Volume13
Issue number1
Publication statusPublished - 1986

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Immunoglobulin Heavy Chains
Lupus Nephritis
HLA-B8 Antigen
Immunoglobulin G
Phenotype
Systemic Lupus Erythematosus
HLA-DR3 Antigen
Heterozygote
Kidney

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Interplay of immunoglobulin G heavy chain markers (Gm) and HLA in predisposing to systemic lupus nephritis. / Stenszky, V.; Kozma, L.; Szegedi, G.; Farid, N. R.

In: Journal of Immunogenetics, Vol. 13, No. 1, 1986, p. 11-17.

Research output: Contribution to journalArticle

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