Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse

Shan Wang, Melinda Erzsebet Toth, Erika Bereczki, M. Sántha, Zhi Zhong Guan, Bengt Winblad, Jin Jing Pei

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The association between heat shock protein 27 (Hsp27) and hyperphosphorylated tau has gained attention for more than a decade, but it has never been explored in vivo. In the present study, we found that tau phosphorylated at S396/404 (PHF-1) and S262 sites was significantly increased in the cerebellum of Hsp27 transgenic mice, which was concomitant with increased glycogen synthase kinase-3β (GSK3β) phosphorylated at Y216 and decreased GSK3β phosphorylated at S9. Neither 70-kDa ribosomal protein S6 kinase (p70S6K; total p70S6K, p70S6K at T389, and p70S6K at T421/S424) nor protein phosphatase PP2A (total PP2A, PP2A at Y307, methylated or demethylated PP2A) was changed. This suggests that the increased tau phosphorylation at S396/404 and S262 sites may be induced by Hsp27 through enhancement of GSK3β activity in the mouse cerebellum.

Original languageEnglish
Pages (from-to)1267-1275
Number of pages9
JournalJournal of Neuroscience Research
Volume89
Issue number8
DOIs
Publication statusPublished - Aug 2011

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HSP27 Heat-Shock Proteins
70-kDa Ribosomal Protein S6 Kinases
Glycogen Synthase Kinase 3
Cerebellum
Transgenic Mice
Phosphoprotein Phosphatases
Phosphorylation

Keywords

  • Alzheimer's disease
  • Glycogen synthase kinase 3
  • Heat shock protein 27
  • Transgenic mice

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse. / Wang, Shan; Toth, Melinda Erzsebet; Bereczki, Erika; Sántha, M.; Guan, Zhi Zhong; Winblad, Bengt; Pei, Jin Jing.

In: Journal of Neuroscience Research, Vol. 89, No. 8, 08.2011, p. 1267-1275.

Research output: Contribution to journalArticle

Wang, Shan ; Toth, Melinda Erzsebet ; Bereczki, Erika ; Sántha, M. ; Guan, Zhi Zhong ; Winblad, Bengt ; Pei, Jin Jing. / Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse. In: Journal of Neuroscience Research. 2011 ; Vol. 89, No. 8. pp. 1267-1275.
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AU - Guan, Zhi Zhong

AU - Winblad, Bengt

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