Interneuron Diversity series: Rhythm and mood in perisomatic inhibition

Research output: Contribution to journalArticle

464 Citations (Scopus)

Abstract

GABAergic interneurons innervating the perisomatic region of pyramidal cells control population discharge patterns, and thereby all cognitive operations in the cerebral cortex. A striking dichotomy in the function of this interneuron population seems to emerge from the synthesis of recent molecular, anatomical and electrophysiological data. Synaptically and electrically coupled networks of parvalbumin-containing basket cells operate as a non-plastic, precision clockwork for gamma and theta oscillations, and are indispensable for basic cortical processing. By contrast, a highly modifiable interneuron syncytium containing cholecystokinin carries information from subcortical pathways about the emotional, motivational and general physiological state of the animal, and appears to be involved in the fine-tuning of network cooperativity. Impairment of this inhibitory mechanism is likely to result in mood disorders such as anxiety.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalTrends in Neurosciences
Volume26
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

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Interneurons
Parvalbumins
Pyramidal Cells
Cholecystokinin
Giant Cells
Mood Disorders
Cerebral Cortex
Population
Anxiety
Inhibition (Psychology)

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Interneuron Diversity series : Rhythm and mood in perisomatic inhibition. / Freund, T.

In: Trends in Neurosciences, Vol. 26, No. 9, 01.09.2003, p. 489-495.

Research output: Contribution to journalArticle

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