International commission for protection against environmental mutagens and carcinogens

ICPEMC working paper no. 10 - A new approach to germinal mutation surveillance: Pair-wise evaluation of component elements in unidentified multiple congenital abnormalities

Agnes Kis-Varga, Thomas Rudas, Andrew Czeizel, J. D. Jansen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the Hungarian population-based surveillance of germinal mutations, 3 indicator conditions of offspring are being followed, namely 15 sentinel anomalies, Down syndrome and unidentified multiple congenital abnormality. The latter is discussed here as a possible indicator of germinal dominant gene and chromosomal mutations. The component congenital abnormalities of unidentified multiple congenital abnormalities are classified into 45 groups. The component congenital abnormalities were reduced to pairs. A pair is a set of 2 independent component congenital abnormalities in index patients with 2 or more congenital abnormalities. Baseline figures of all component congenital abnormality pairs in 3722 unidentified multiple congenital abnormalities were determined in the study period 1973-1982. The observed data for 1983 were compared with expected occurrences based on baseline figures. This pair-wise evaluation of component elements within unidentified multiple congenital abnormalities seems to be an adequate surveillance method to detect any time cluster of congenital abnormality pairs due to environmental factors including germinal mutagens.

Original languageEnglish
Pages (from-to)87-97
Number of pages11
JournalMutation Research - Reviews in Mutation Research
Volume238
Issue number1
Publication statusPublished - 1990

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Environmental Carcinogens
Multiple Abnormalities
Mutagens
Mutation
Population Surveillance
Dominant Genes
Down Syndrome

Keywords

  • Germinal mutation surveillance
  • Hungary
  • Unidentified multiple congenital abnormalities

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis

Cite this

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