Transferrin-iron(III)-anion complexes internalization and cytotoxic effects were determinedonglioblastoma cells. The Tf-complexes cellular uptake was followed by fluorescent labelling of the protein. Cellular incorporation testshows the highest efficacy of transferrin-iron-bicarbonatecomplex. The induced cell membrane demageand the decrease of mitochondrial activity prove the aziridine-carboxylate toxicity on stem cell-like glioblastomamulti formebrain cancer cells.
|Number of pages||10|
|Journal||Studia Universitatis Babes-Bolyai Chemia|
|Publication status||Published - Nov 12 2013|
- Cellular uptake
- Glioblastoma cells
- Transferrin complexes
ASJC Scopus subject areas