Internal lever arm model for myosin II

Andras Bibó, M. Kovács, Gyorgy Karolyi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Motor proteins are special enzymes capable of transforming chemical energy into mechanical work. One of the best known motor proteins belongs to the family of myosins found in eukaryotic tissues. The most studied - and first discovered - type of myosin is the skeletal muscle myosin (myosin II) which is the motor protein responsible for the contraction of muscle tissue. In the present study we propose an overdamped visco-elastic rigid body model, linked with springs, for myosin II, where an internal lever arm is added to the previously investigated lever arm model. Our model is based on the significant difference of two springs' stiffness, which is responsible for the sequence of steps of the motion (binding to actin vs. lever arm swinging). The model provides exponential time-displacement curves which are consistent with experimental measurements.

Original languageEnglish
Title of host publicationIUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments - Proceedings of the IUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments
PublisherSpringer Verlag
Pages153-163
Number of pages11
ISBN (Print)9789400716421
Publication statusPublished - Jan 1 2011
EventIUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments, 2010 - Budapest, Hungary
Duration: Jun 7 2010Jun 11 2010

Publication series

NameIUTAM Bookseries
Volume30
ISSN (Print)1875-3507

Other

OtherIUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments, 2010
CountryHungary
CityBudapest
Period6/7/106/11/10

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ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Bibó, A., Kovács, M., & Karolyi, G. (2011). Internal lever arm model for myosin II. In IUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments - Proceedings of the IUTAM Symposium on Dynamics Modeling and Interaction Control in Virtual and Real Environments (pp. 153-163). (IUTAM Bookseries; Vol. 30). Springer Verlag.