Internal and external information processing by lateral hypothalamic glucose-sensitive and insensitive neurons during bar press feeding in the monkey

H. Nishino, Y. Oomura, Z. Karádi, S. Aou, L. Lénárd, Y. Kai, A. Fukuda, C. Ito, B. I. Min, C. P. Salamant

Research output: Contribution to journalArticle

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Abstract

Single neuron activities in the lateral hypothalamic area (LHA) were recorded during bar press feeding task in the monkey. First registered neurons were sorted into 2 groups, glucose-sensitive (GS) and glucose-insensitive (GIS) neurons, depending on their glucose sensitivity. Then firing variations to feeding, electrophoretically applied catecholamines and opiate, and to odor and taste stimuli were investigated. GS neurons responded to dopamine, noradrenaline and morphine more often than GIS neurons. In feeding task GS neurons responded during bar press (BP) and reward (RW) periods with long-lasting inhibition of firing and at cue tone (CT) with transient inhibition, while GIS neurons responded during BP and RW periods mainly with excitation and at cue light (CL) with excitation. A majority of GS neurons responded to both odor and taste stimuli more often than GIS neurons. Data suggest that these two kinds of neurons in the LHA may be involved in different functional aspects of feeding: GS neurons, mainly in internal information processing and reward mechanism, and GIS neurons, in external information processing and motor aspects.

Original languageEnglish
Pages (from-to)839-845
Number of pages7
JournalBrain Research Bulletin
Volume20
Issue number6
DOIs
Publication statusPublished - 1988

Fingerprint

Automatic Data Processing
Haplorhini
Neurons
Glucose
Reward
Lateral Hypothalamic Area
Cues
Opiate Alkaloids
Morphine
Catecholamines
Dopamine
Norepinephrine
Light

Keywords

  • Catecholamine
  • Feeding
  • Glucose-sensitive neuron
  • Lateral hypothalamic area
  • Monkey
  • Odor
  • Single neuron activity
  • Taste

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Internal and external information processing by lateral hypothalamic glucose-sensitive and insensitive neurons during bar press feeding in the monkey. / Nishino, H.; Oomura, Y.; Karádi, Z.; Aou, S.; Lénárd, L.; Kai, Y.; Fukuda, A.; Ito, C.; Min, B. I.; Salamant, C. P.

In: Brain Research Bulletin, Vol. 20, No. 6, 1988, p. 839-845.

Research output: Contribution to journalArticle

Nishino, H. ; Oomura, Y. ; Karádi, Z. ; Aou, S. ; Lénárd, L. ; Kai, Y. ; Fukuda, A. ; Ito, C. ; Min, B. I. ; Salamant, C. P. / Internal and external information processing by lateral hypothalamic glucose-sensitive and insensitive neurons during bar press feeding in the monkey. In: Brain Research Bulletin. 1988 ; Vol. 20, No. 6. pp. 839-845.
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