Intermittent hypoxic loading: a model system to study the early stages of myocardial lesions

E. Somogyi, P. Sotonyi, A. Nemes, S. Juhasz-Nagy

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1 Citation (Scopus)

Abstract

The authors applied the model system of intermittent hypoxic loading to study the development of early myocardial alterations. It was found that a primary role is played by the deficiency of high-energy phosphate synthesis and by the disturbance of energetic and transport processes. The change of Ca2+-control, activation of anaerobic glycolysis and intracellular acidosis were found to be instrumental in decreasing contractility, impairing membranes and finally in a diffuse destruction of myofilaments.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalActa morphologica Academiae Scientiarum Hungaricae
Volume25
Issue number4
Publication statusPublished - Dec 1 1977

ASJC Scopus subject areas

  • Anatomy

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