Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications

Lili Magyari, Dalma Varszegi, Erzsebet Kovesdi, Patricia Sarlos, Bernadett Farago, Andras Javorhazy, Katalin Sumegi, Zsolt Banfai, Bela Melegh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologic targets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.

Original languageEnglish
Pages (from-to)516-536
Number of pages21
JournalWorld Journal of Orthopaedics
Volume5
Issue number4
DOIs
Publication statusPublished - 2014

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Keywords

  • Immunologic targets
  • Interleukins
  • Polymorphisms
  • Rheumatoid arthritis
  • Therapy

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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