Interleukins and interleukin receptors in rheumatoid arthritis

Research, diagnostics and clinical implications

L. Magyari, Dalma Varszegi, Erzsebet Kovesdi, Patricia Sarlos, Bernadett Farago, Andras Javorhazy, Katalin Sumegi, Zsolt Banfai, B. Melegh

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologic targets for RA treatment. The identification of diseaseassociated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.

Original languageEnglish
Pages (from-to)516-536
Number of pages21
JournalWorld Journal of Orthopaedics
Volume5
Issue number4
DOIs
Publication statusPublished - 2014

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Interleukin Receptors
Interleukins
Rheumatoid Arthritis
Research
Precision Medicine
Genes
Autoimmune Diseases
Patient Care
Therapeutics
Joints
Delivery of Health Care

Keywords

  • Immunologic targets
  • Interleukins
  • Polymorphisms
  • Rheumatoid arthritis
  • Therapy

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Interleukins and interleukin receptors in rheumatoid arthritis : Research, diagnostics and clinical implications. / Magyari, L.; Varszegi, Dalma; Kovesdi, Erzsebet; Sarlos, Patricia; Farago, Bernadett; Javorhazy, Andras; Sumegi, Katalin; Banfai, Zsolt; Melegh, B.

In: World Journal of Orthopaedics, Vol. 5, No. 4, 2014, p. 516-536.

Research output: Contribution to journalArticle

Magyari, L. ; Varszegi, Dalma ; Kovesdi, Erzsebet ; Sarlos, Patricia ; Farago, Bernadett ; Javorhazy, Andras ; Sumegi, Katalin ; Banfai, Zsolt ; Melegh, B. / Interleukins and interleukin receptors in rheumatoid arthritis : Research, diagnostics and clinical implications. In: World Journal of Orthopaedics. 2014 ; Vol. 5, No. 4. pp. 516-536.
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