Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility

Lili Magyari, Erzsebet Kovesdi, Patricia Sarlos, Andras Javorhazy, Katalin Sumegi, Bela Melegh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals. Genetic markers are associated with disease phenotype and long-term evolution, but their value in everyday clinical practice is limited at the moment. IBD has a clear immunological background and interleukins play key role in the process. Almost 130 original papers were revised including meta-analy-sis. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but text often do not available for the doctors use these in the clinical practice nowadays. We conducted a systematic review of the

Original languageEnglish
Pages (from-to)3208-3222
Number of pages15
JournalWorld journal of gastroenterology
Volume20
Issue number12
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Crohn's disease
  • Inflammatory bowel disease
  • Interleukin
  • Interleukin receptor
  • Polymorphisms
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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