Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes

P. Arenberger, L. Kemény, R. Suss, G. Michel, R. U. Peter, T. Ruzicka

Research output: Contribution to journalArticle

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Abstract

Polymorphonuclear leukocyte (PMNL) infiltration is an important characteristic in psoriatic lesions. The proinflammatory 8-kD) peptide interleukin-8 (IL-8) is present in psoriatic scales and possesses a high chemotactic activity on human neutrophils which may relate to its role in psoriasis. Its chemotactic activity is mediated via specific receptors on PMNL. The goal of our work was to ascertain whether PMNL infiltration in psoriasis can be accounted for by functional abnormalities of the circulating PMNL due to alterations in the IL-8 receptor density or affinity (or both). Results of radioligand binding studies performed in 10 psoriatic patients, 10 patients with atopic eczema and 11 normal controls showed no difference in receptor affinity (K(d)) between the groups. However, a slight but significant elevation in IL-8 receptor density was seen on PMNL from psoriatic individuals (31,230±3,237 binding sites per cell) compared to those from normal volunteers (24,152±2,643) and atopic eczema patients (24,092±2,743). Increased number of IL-8 receptors may, besides elevated cutaneous IL-8 concentrations, contribute to the intraepidermal accumulation of PMNL in psoriasis.

Original languageEnglish
Pages (from-to)334-336
Number of pages3
JournalActa Dermato-Venereologica
Volume72
Issue number5
Publication statusPublished - 1992

Fingerprint

Interleukin-8 Receptors
Neutrophils
Psoriasis
Atopic Dermatitis
Interleukin-8
Human Activities
Healthy Volunteers
Binding Sites
Skin
Peptides

Keywords

  • Interleukin-8
  • Leukocytes
  • Psoriasis
  • Receptors

ASJC Scopus subject areas

  • Dermatology

Cite this

Arenberger, P., Kemény, L., Suss, R., Michel, G., Peter, R. U., & Ruzicka, T. (1992). Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes. Acta Dermato-Venereologica, 72(5), 334-336.

Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes. / Arenberger, P.; Kemény, L.; Suss, R.; Michel, G.; Peter, R. U.; Ruzicka, T.

In: Acta Dermato-Venereologica, Vol. 72, No. 5, 1992, p. 334-336.

Research output: Contribution to journalArticle

Arenberger, P, Kemény, L, Suss, R, Michel, G, Peter, RU & Ruzicka, T 1992, 'Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes', Acta Dermato-Venereologica, vol. 72, no. 5, pp. 334-336.
Arenberger P, Kemény L, Suss R, Michel G, Peter RU, Ruzicka T. Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes. Acta Dermato-Venereologica. 1992;72(5):334-336.
Arenberger, P. ; Kemény, L. ; Suss, R. ; Michel, G. ; Peter, R. U. ; Ruzicka, T. / Interleukin-8 receptors in normal and psoriatic polymorphonuclear leukocytes. In: Acta Dermato-Venereologica. 1992 ; Vol. 72, No. 5. pp. 334-336.
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