Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells

Günter Michel, L. Kemény, Ralf U. Peter, Axel Beetz, Christine Ried, Petr Arenberger, Thomas Ruzicka

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Normal human keratinocytes show chemotactic behavior towards interleukin-8 (IL-8). Under physiological conditions this cylokine seems to be present in an equilibrium between monomeric and dimeric forms, as indicated by Western blotting data. Radioligand binding studies suggest that keratinocyte chemotaxis is mediated by receptors specific for IL-8 dimers. IL-8 rcceptor-specific mRNA can be detected in a keratinocyte cell line by polymerase chain reaction.

Original languageEnglish
Pages (from-to)241-243
Number of pages3
JournalFEBS Letters
Volume305
Issue number3
DOIs
Publication statusPublished - Jul 6 1992

Fingerprint

Interleukin-8 Receptors
Chemotaxis
Interleukin-8
Keratinocytes
Polymerase chain reaction
Dimers
Western Blotting
Cells
Cell Line
Polymerase Chain Reaction
Messenger RNA

Keywords

  • Human keratinocyte
  • IL-8 dimer
  • Interleukin-8 receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Michel, G., Kemény, L., Peter, R. U., Beetz, A., Ried, C., Arenberger, P., & Ruzicka, T. (1992). Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells. FEBS Letters, 305(3), 241-243. https://doi.org/10.1016/0014-5793(92)80677-9

Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells. / Michel, Günter; Kemény, L.; Peter, Ralf U.; Beetz, Axel; Ried, Christine; Arenberger, Petr; Ruzicka, Thomas.

In: FEBS Letters, Vol. 305, No. 3, 06.07.1992, p. 241-243.

Research output: Contribution to journalArticle

Michel, G, Kemény, L, Peter, RU, Beetz, A, Ried, C, Arenberger, P & Ruzicka, T 1992, 'Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells', FEBS Letters, vol. 305, no. 3, pp. 241-243. https://doi.org/10.1016/0014-5793(92)80677-9
Michel, Günter ; Kemény, L. ; Peter, Ralf U. ; Beetz, Axel ; Ried, Christine ; Arenberger, Petr ; Ruzicka, Thomas. / Interleukin-8 receptor-mediated chemotaxis of normal human epidermal cells. In: FEBS Letters. 1992 ; Vol. 305, No. 3. pp. 241-243.
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